UniProt Accession

 KLH13_HUMAN; Q9P2N7; B3KV78; B3KWM7; B7Z3S9; B7Z5P2; B7Z802; D3DWH6; Q6P2E3; Q96QI7; Q9UDN9 

Genbank Protein ID

 AB037730; AL591986; AK122724; AK125356; AK296324; AK299257; AK302713; AC006968; AC006963; CH471161; CH471161; BC064576 

Genbank Nucleotide ID

 BAA92547.1; CAC41335.1; BAG53690.1; BAG54189.1; BAH12315.1; BAH12978.1; BAH13788.1; AAF03529.1; EAW89898.1; EAW89900.1; AAH64576.2 

Protein Name

 Kelch-like protein 13 

Protein Synonyms/Alias

 BTB and kelch domain-containing protein 2 

Gene Name

 KLHL13 

Gene Synonyms/Alias

 BKLHD2; KIAA1309 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
62	SSHLQSSKAGPTRIF	ubiquitination	[1]
136	EQDLMCIKLHGVSKV	ubiquitination	[2]
213	YNLTEVDKYVNSFVL	ubiquitination	[1, 2, 3]
221	YVNSFVLKNFPALLS	ubiquitination	[2, 3]
277	PRMDFAAKLMKNIRF	ubiquitination	[1, 2, 3]
280	DFAAKLMKNIRFPLM	ubiquitination	[3]
365	ELRMYDEKAHEWKSL	ubiquitination	[4]
370	DEKAHEWKSLAPMDA	ubiquitination	[1, 3]
405	SNYDTKGKTAVDTVF	ubiquitination	[4]
618	PDKDEWHKVFDLPES	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. 

Sequence Annotation

 DOMAIN 92 161 BTB.
 DOMAIN 196 297 BACK.
 REPEAT 341 389 Kelch 1.
 REPEAT 390 441 Kelch 2.
 REPEAT 442 488 Kelch 3.
 REPEAT 490 535 Kelch 4.
 REPEAT 537 587 Kelch 5.
 REPEAT 588 636 Kelch 6.  

Keyword

 Alternative splicing; Cell cycle; Cell division; Complete proteome; Kelch repeat; Mitosis; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 655 AA 

Protein Sequence

Gene Ontology

 GO:0031463; C:Cul3-RING ubiquitin ligase complex; IDA:UniProtKB.
 GO:0000910; P:cytokinesis; IMP:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0016567; P:protein ubiquitination; IDA:UniProtKB. 

Interpro

 IPR011705; BACK.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR015916; Gal_Oxidase_b-propeller.
 IPR017096; Kelch-like_gigaxonin.
 IPR006652; Kelch_1. 

Pfam

 PF07707; BACK
 PF00651; BTB
 PF01344; Kelch_1 

SMART

 SM00875; BACK
 SM00225; BTB
 SM00612; Kelch 

PROSITE

 PS50097; BTB 

PRINTS