CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026889
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine hydroxymethyltransferase 
Protein Synonyms/Alias
  
Gene Name
 Shmt1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
217TVWASHEKMLTQPLKacetylation[1]
224KMLTQPLKESDAEVYacetylation[1]
235AEVYSIIKKESNRQRacetylation[1]
354THGFMTDKKKISATSacetylation[1]
563ILMDLRPKGTDGGRAacetylation[1]
646RATLKEFKEKLTGDEacetylation[1]
654EKLTGDEKFQSAVAAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Interconversion of serine and glycine (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; One-carbon metabolism; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 681 AA 
Protein Sequence
MELTVEAWVQ IFLLPVEKSD PVSRLDPDRM GHVKGPVQMI QNCRISTTQG NNRITQRSPG 60
YTPDSPTKSF SLWNSQNLLV QSMKLAASAV SIWFWGSWRI PRELLVFSLH WNLKEVGLST 120
SPSNSTNLPA RVKGKQAEKQ SFLLLSSFIW VAIRSYSSFC QVLPKFLLRA RANGAWAAEG 180
GLYLDPPTDW AALGVGRGQP RCAMAERDAT VWASHEKMLT QPLKESDAEV YSIIKKESNR 240
QRVGLELIAS ENFASRAVLE ALGSCLNNKY SEGYPGQRYY GGTEFIDELE TLCQKRALQA 300
YHLDPQCWGV NVQPYSGSPA NFAVYTALVE PHGRIMGLDL PDGGHLTHGF MTDKKKISAT 360
SIFFESMPYK VYPDTGYINY DQLEENASLF HPKLIIAGTS CYSRNLDYAR LRKIADDNGA 420
YLMADMAHIS GLVAAGVVPS PFEHCHVVTT TTHKTLRGCR AGMIFYRKGV RSVDPKTGEE 480
TYYELESLIN SAVFPGLQGG PHNHAIAGVA VALKQAMTTE FKIYQLQVLA NCRALSDALT 540
ELGYKIVTGG SDNHLILMDL RPKGTDGGRA EKVLEACSIA CNKNTCPGDK SALRPSGLRL 600
GTPALTSRGL LEEDFQKIAH FIHRGIELTL QIQSHMTMRA TLKEFKEKLT GDEKFQSAVA 660
ALREEVENFA SNFSLPGLPD F 681 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0016597; F:amino acid binding; IPI:RGD.
 GO:0004372; F:glycine hydroxymethyltransferase activity; IDA:RGD.
 GO:0042802; F:identical protein binding; IDA:RGD.
 GO:0008732; F:L-allo-threonine aldolase activity; IDA:RGD.
 GO:0030170; F:pyridoxal phosphate binding; IDA:RGD.
 GO:0046655; P:folic acid metabolic process; IEA:Compara.
 GO:0019264; P:glycine biosynthetic process from serine; IDA:RGD.
 GO:0006565; P:L-serine catabolic process; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IDA:RGD.
 GO:0009113; P:purine nucleobase biosynthetic process; IEA:Compara.
 GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. 
Interpro
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR001085; Ser_HO-MeTrfase.
 IPR019798; Ser_HO-MeTrfase_PLP_BS. 
Pfam
 PF00464; SHMT 
SMART
  
PROSITE
 PS00096; SHMT 
PRINTS