CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003673
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transcription factor YY2 
Protein Synonyms/Alias
 Yin and yang 2; YY-2 
Gene Name
 Yy2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
301KAFVESSKLKRHQLVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation (By similarity). 
Sequence Annotation
 ZN_FING 258 282 C2H2-type 1.
 ZN_FING 287 309 C2H2-type 2.
 ZN_FING 315 339 C2H2-type 3.
 ZN_FING 345 369 C2H2-type 4.
 REGION 36 109 Mediates transcriptional activation (By
 REGION 241 376 Mediates transcriptional repression (By  
Keyword
 Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 376 AA 
Protein Sequence
MASDTEKLMC LTTENAEIPA DFVELQPLDE IETVSLETNV SQTIEVYGDV GVDWAHGGHY 60
HSPLIALQPL AGSNLSNGDH DQEMIIVQTR EEVVDYQDSD NLLLGTEFES QMVLPVNEDD 120
YLQPTTATFS GFMAAENGQD ELSPYGGNLC GLTTIIEAGA EEGVNPDLGD KQWEQKQIQI 180
DGLDGEFPFA MWEDNNLKED PVAEEEAGES TPDYSEYMTG KKFPPEGIPG IDLSDPKQLA 240
EFTSMKPKKP KGDFPRPVAC SHKGCGKMFK DNSAMRKHLH IHGPRVHVCA ECGKAFVESS 300
KLKRHQLVHT GEKPYQCTFE GCGRRFSLDF NLRTHVRIHT GDKPFVCPFD ACNKKFAQST 360
NLKSHILTHV KNKNDQ 376 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR017114; TF_Yin_yang.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS