UniProt Accession

 E7EMI5_HUMAN; E7EMI5 

Genbank Protein ID

 AP001413; AP001421; AP001428; AP001437 

Genbank Nucleotide ID

  

Protein Name

 Dual-specificity tyrosine-phosphorylation-regulated kinase 1A 

Protein Synonyms/Alias

  

Gene Name

 DYRK1A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	GGETSACKPSSVRLA	methylation	[1]
105	VDLIKTYKHINEVYY	acetylation	[2]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 131 AA 

Protein Sequence

Gene Ontology

 GO:0016607; C:nuclear speck; IEA:Compara.
 GO:0030529; C:ribonucleoprotein complex; IEA:Compara.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:Compara.
 GO:0004713; F:protein tyrosine kinase activity; IEA:Compara.
 GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Compara.
 GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Compara.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0090312; P:positive regulation of protein deacetylation; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS