CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016662
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 EGF domain-specific O-linked N-acetylglucosamine transferase 
Protein Synonyms/Alias
 Extracellular O-linked N-acetylglucosamine transferase 
Gene Name
 Eogt 
Gene Synonyms/Alias
 Aer61; Eogt1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
174KRNHDRFKEDFLQGGacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. 
Sequence Annotation
 MOTIF 524 527 Prevents secretion from ER (Potential).
 CARBOHYD 354 354 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Reference proteome; Signal; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 527 AA 
Protein Sequence
MLMLLVFGVL LHEVPLSGQD KAHSEADDAP GKALYDYSSL RLPAEHIPFF LHNNRHVASV 60
CREDSHCPYK KHLENLNYCW GYEKSCAPEF RFGSPVCSYV DLGWTDTLES AQDMFWRQAD 120
FGYARERLGE IRTICQPERA SDSSLVCSRY LQYCRATGLY LDLRNIKRNH DRFKEDFLQG 180
GEIGGYCKLD SHALVSEGQR KSPLQSWFAE LQGYTQLNFR PIEDAKCDIV VEKPTYFMKL 240
DAGINMYHHF CDFLNLYLTQ HVNNSFSTDV YIVMWDTSTY GYGDLFSDTW KAFTDYDVIH 300
LKTYDSKKVC FKEAVFSLLP RMRYGLFYNT PLISGCQNTG LFRAFSQHVL HRLNITQEGP 360
KDGKVRVTIL ARSTEYRKIL NQDELVNALK TVSTFEVRVV DYKYRELGFL DQLRITHNTD 420
IFIGMHGAGL THLLFLPDWA AVFELYNCED ERCYLDLARL RGIHYITWRK PSKVFPQDKG 480
HHPTLGEHPK FTNYSFDVEE FMYLVLQAAE HVLQHPQWPF KKKHDEL 527 
Gene Ontology
 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0016262; F:protein N-acetylglucosaminyltransferase activity; IDA:UniProtKB.
 GO:0006493; P:protein O-linked glycosylation; IDA:UniProtKB. 
Interpro
 IPR007657; Glycosyltransferase_AER61. 
Pfam
 PF04577; DUF563 
SMART
  
PROSITE
 PS00014; ER_TARGET 
PRINTS