CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032170
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ADP-ribosylation factor GTPase-activating protein 1 
Protein Synonyms/Alias
 cDNA FLJ55014, highly similar to ADP-ribosylation factor GTPase-activating protein 1 
Gene Name
 ARFGAP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
49SVTASSDKAFEDWLNubiquitination[1]
118AAKEGATKFGSQASQacetylation[2]
118AAKEGATKFGSQASQubiquitination[3]
165GVSQLASKVQGVGSKubiquitination[2, 3, 4, 5]
172KVQGVGSKGWRDVTTubiquitination[3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 293 AA 
Protein Sequence
MLSSESSWSL RRITILAGPC RRSTTAEPRP SLGIRVSGQP QSVTASSDKA FEDWLNDDLG 60
SYQGAQGNRY VGFGNTPPPQ KKEDDFLNNA MSSLYSGWSS FTTGASRFAS AAKEGATKFG 120
SQASQKASEL GHSLNENVLK PAQEKVKEGK IFDDVSSGVS QLASKVQGVG SKGWRDVTTF 180
FSGKAEGPLD SPSEGHSYQN SGLDHFQNSN IDQSFWETFG SAEPTKTRKS PSSDSWTCAD 240
TSTERRSSDS WEVWGSASTN RNSNSDGGEG GEGTKKAVPP AVPTDDGWDN QNW 293 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS