CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023161
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cell cycle progression protein 1 
Protein Synonyms/Alias
 Cell cycle progression restoration protein 8 
Gene Name
 CCPG1 
Gene Synonyms/Alias
 CCP8; CPR8; KIAA1254 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
300KMSFETQKTNLATENubiquitination[1]
482HRAKNKSKETFLGSVubiquitination[2]
530KKFSDSVKSTFRHFKubiquitination[2]
537KSTFRHFKDTTKNIFubiquitination[2]
705TDFVNDVKDYLRNMKubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation. 
Sequence Annotation
 REGION 1 308 Interaction with MCF2L and SRC (By  
Keyword
 Alternative splicing; Cell cycle; Coiled coil; Complete proteome; Membrane; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 757 AA 
Protein Sequence
MSENSSDSDS SCGWTVISHE GSDIEMLNSV TPTDSCEPAP ECSSLEQEEL QALQIEQGES 60
SQNGTVLMEE TAYPALEETS STIEAEEQKI PEDSIYIGTA SDDSDIVTLE PPKLEEIGNQ 120
EVVIVEEAQS SEDFNMGSSS SSQYTFCQPE TVFSSQPSDD ESSSDETSNQ PSPAFRRRRA 180
RKKTVSASES EDRLVAEQET EPSKELSKRQ FSSGLNKCVI LALVIAISMG FGHFYGTIQI 240
QKRQQLVRKI HEDELNDMKD YLSQCQQEQE SFIDYKSLKE NLARCWTLTE AEKMSFETQK 300
TNLATENQYL RVSLEKEEKA LSSLQEELNK LREQIRILED KGTSTELVKE NQKLKQHLEE 360
EKQKKHSFLS QRETLLTEAK MLKRELERER LVTTALRGEL QQLSGSQLHG KSDSPNVYTE 420
KKEIAILRER LTELERKLTF EQQRSDLWER LYVEAKDQNG KQGTDGKKKG GRGSHRAKNK 480
SKETFLGSVK ETFDAMKNST KEFVRHHKEK IKQAKEAVKE NLKKFSDSVK STFRHFKDTT 540
KNIFDEKGNK RFGATKEAAE KPRTVFSDYL HPQYKAPTEN HHNRGPTMQN DGRKEKPVHF 600
KEFRKNTNSK KCSPGHDCRE NSHSFRKACS GVFDCAQQES MSLFNTVVNP IRMDEFRQII 660
QRYMLKELDT FCHWNELDQF INKFFLNGVF IHDQKLFTDF VNDVKDYLRN MKEYEVDNDG 720
VFEKLDEYIY RHFFGHTFSP PYGPRSVYIK PCHYSSL 757 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:2001106; P:regulation of Rho guanyl-nucleotide exchange factor activity; IEA:Compara. 
Interpro
 IPR024889; Ccpg1. 
Pfam
  
SMART
  
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PRINTS