CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017518
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Discoidin, CUB and LCCL domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 DCBLD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
529NEKEMTQKLDLITSDubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
 DOMAIN 41 150 CUB.
 DOMAIN 152 248 LCCL.
 DOMAIN 248 412 F5/8 type C.
 CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
 CARBOHYD 124 124 N-linked (GlcNAc...) (Potential).
 CARBOHYD 277 277 N-linked (GlcNAc...) (Potential).
 CARBOHYD 351 351 N-linked (GlcNAc...) (Potential).
 CARBOHYD 418 418 N-linked (GlcNAc...) (Potential).
 CARBOHYD 455 455 N-linked (GlcNAc...) (Potential).
 DISULFID 41 68 By similarity.
 DISULFID 94 112 By similarity.
 DISULFID 158 174 By similarity.
 DISULFID 178 200 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 715 AA 
Protein Sequence
MVPGARGGGA LARAAGRGLL ALLLAVSAPL RLQAEELGDG CGHLVTYQDS GTMTSKNYPG 60
TYPNHTVCEK TITVPKGKRL ILRLGDLDIE SQTCASDYLL FTSSSDQYGP YCGSMTVPKE 120
LLLNTSEVTV RFESGSHISG RGFLLTYASS DHPDLITCLE RASHYLKTEY SKFCPAGCRD 180
VAGDISGNMV DGYRDTSLLC KAAIHAGIIA DELGGQISVL QRKGISRYEG ILANGVLSRD 240
GSLSDKRFLF TSNGCSRSLS FEPDGQIRAS SSWQSVNESG DQVHWSPGQA RLQDQGPSWA 300
SGDSSNNHKP REWLEIDLGE KKKITGIRTT GSTQSNFNFY VKSFVMNFKN NNSKWKTYKG 360
IVNNEEKVFQ GNSNFRDPVQ NNFIPPIVAR YVRVVPQTWH QRIALKVELI GCQITQGNDS 420
LVWRKTSQST SVSTKKEDET ITRPIPSEET STGINITTVA IPLVLLVVLV FAGMGIFAAF 480
RKKKKKGSPY GSAEAQKTDC WKQIKYPFAR HQSAEFTISY DNEKEMTQKL DLITSDMADY 540
QQPLMIGTGT VTRKGSTFRP MDTDAEEAGV STDAGGHYDC PQRAGRHEYA LPLAPPEPEY 600
ATPIVERHVL RAHTFSAQSG YRVPGPQPGH KHSLSSGGFS PVAGVGAQDG DYQRPHSAQP 660
ADRGYDRPKA VSALATESGH PDSQKPPTHP GTSDSYSAPR DCLTPLNQTA MTALL 715 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0007155; P:cell adhesion; IEA:InterPro. 
Interpro
 IPR000421; Coagulation_fac_5/8-C_type_dom.
 IPR000859; CUB_dom.
 IPR008979; Galactose-bd-like.
 IPR004043; LCCL. 
Pfam
 PF00431; CUB
 PF00754; F5_F8_type_C
 PF03815; LCCL 
SMART
 SM00042; CUB
 SM00231; FA58C 
PROSITE
 PS01180; CUB
 PS01285; FA58C_1
 PS01286; FA58C_2
 PS50022; FA58C_3
 PS50820; LCCL 
PRINTS