CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010703
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 ubiquitin-protein ligase RBBP6 
Protein Synonyms/Alias
 Proliferation potential-related protein; Protein P2P-R; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis 
Gene Name
 Rbbp6 
Gene Synonyms/Alias
 P2pr; Pact 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
130ANASEEDKIKAMMSQacetylation[1, 2]
218AMLTNTGKYAIPTIDacetylation[3]
844EWYEKYYKGYAVGAQacetylation[3]
1023KSDKTKRKSDGSATAacetylation[3]
1031SDGSATAKKDNVLKPacetylation[3]
1345QPIQSVGKPSSIIKNacetylation[3]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation. 
Sequence Annotation
 DOMAIN 4 76 DWNN.
 ZN_FING 160 177 CCHC-type.
 ZN_FING 260 301 RING-type; degenerate.
 REGION 983 1139 Interaction with RB1.
 REGION 1434 1544 Interaction with p53.
 MOD_RES 245 245 Phosphoserine (By similarity).
 MOD_RES 246 246 Phosphoserine (By similarity).
 MOD_RES 247 247 Phosphoserine (By similarity).
 MOD_RES 248 248 Phosphoserine (By similarity).
 MOD_RES 361 361 Phosphoserine (By similarity).
 MOD_RES 517 517 Phosphoserine (By similarity).
 MOD_RES 771 771 Phosphoserine.
 MOD_RES 773 773 Phosphoserine.
 MOD_RES 781 781 Phosphoserine (By similarity).
 MOD_RES 862 862 Phosphoserine.
 MOD_RES 1179 1179 Phosphoserine.
 MOD_RES 1272 1272 Phosphothreonine.
 MOD_RES 1278 1278 Phosphoserine.
 MOD_RES 1329 1329 Phosphoserine.
 MOD_RES 1469 1469 Phosphothreonine (By similarity).
 MOD_RES 1646 1646 Phosphoserine (By similarity).
 MOD_RES 1648 1648 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Ligase; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1790 AA 
Protein Sequence
MSCVHYKFSS KLNYDTVTFD GLHISLCDLK KQIMGREKLK AADSDLQITN AQTKEEYTDD 60
NALIPKNSSV IVRRIPIGGV KSTSKTYVIS RTEPVMGTTK AIDDASASIS LAQLTKTANL 120
AEANASEEDK IKAMMSQSGH EYDPINYMKK TLVGPPPPSY TCFRCGKPGH YIKNCPTNGD 180
KNFESGPRIK KSTGIPRSFM MEVKDPNMKG AMLTNTGKYA IPTIDAEAYA IGKKEKPPFL 240
PEEPSSSSEE DDPIPDELLC LICKDIMTDA VVIPCCGNSY CDECIRTALL ESDEHTCPTC 300
HQNDVSPDAL IANKFLRQAV NNFKNETGYT KRLRKQLPPP PPPVPPPRPL MQRNLQPLMR 360
SPISRQQDPL MIPVTSSSAH SAPSISSLTS NPSALAPSVS GNPSSAPAPV PDITATVSIS 420
VHSEKSDGPF RDSDNKLLPA AALTSEHSKG ASSIAITALM EEKGYQVPVL GTPSLLGQSL 480
LHGQLIPTTG PVRINAARPG GGRPGWEHSN KLGYLVSPPQ QIRRGERSCY RSINRGRHHS 540
ERSQRTQGPS LPATPVFVPV PPPPLYPPPP HTLPLPPGVP PPQFSPQFPP GQPPPAGYSV 600
PPPGFPPAPA NISTPWVSSG VQTAHSNTIP TTQAPPLSRE EFYREQRRLK EEEKKKSKLD 660
EFTNDFAKEL MEYKKIQKER RRSFSRSKSP YSGSSYSRSS YTYSKSRSGS TRSRSYSRSF 720
SRSHSRSYSR SPPYPRRGRG KSRNYRSRSR SHGYHRSRSR SPPYRRYHSR SRSPQAFRGQ 780
SPTKRNVPQG ETEREYFNRY REVPPPYDIK AYYGRSVDFR DPFEKERYRE WERKYREWYE 840
KYYKGYAVGA QPRPSANRED FSPERLLPLN IRNSPFTRGR REDYAAGQSH RNRNLGGNYP 900
EKLSTRDSHN AKDNPKSKEK ESENVPGDGK GNKHKKHRKR RKGEESESFL NPELLETSRK 960
CRESSGIDET KTDTLFVLPS RDDATPVRDE PMDAESITFK SVSDKDKREK DKPKVKSDKT 1020
KRKSDGSATA KKDNVLKPSK GPQEKVDGDR EKSPRSEPPL KKAKEEATKI DSVKPSSSSQ 1080
KDEKVTGTPR KAHSKSAKEH QEAKPAKDEK VKKDCSKDIK SEKPASKDEK AKKPEKNKLL 1140
DSKGEKRKRK TEEKSVDKDF ESSSMKISKV EGTEIVKPSP KRKMEGDVEK LERTPEKDKI 1200
ASSTTPAKKI KLNRETGKKI GNAENASTTK EPSEKLESTS SKIKQEKVKG KAKRKVAGSE 1260
GSSSTLVDYT STSSTGGSPV RKSEEKTDTK RTVIKTMEEY NNDNTAPAED VIIMIQVPQS 1320
KWDKDDFESE EEDVKTTQPI QSVGKPSSII KNVTTKPSAT AKYTEKESEQ PEKLQKLPKE 1380
ASHELMQHEL RSSKGSASSE KGRAKDREHS GSEKDNPDKR KSGAQPDKES TVDRLSEQGH 1440
FKTLSQSSKE TRTSEKHESV RGSSNKDFTP GRDKKVDYDS RDYSSSKRRD ERGELARRKD 1500
SPPRGKESLS GQKSKLREER DLPKKGAESK KSNSSPPRDK KPHDHKAPYE TKRPCEETKP 1560
VDKNSGKERE KHAAEARNGK ESSGGKLPCI PNPPDPPMEK ELAAGQVEKS AVKPKPQLSH 1620
SSRLSSDLTR ETDEAAFEPD YNESDSESNV SVKEEEAVAS ISKDLKEKTT EKAKESLTVA 1680
TASQPGADRS QSQSSPSVSP SRSHSPSGSQ TRSHSSSASS AGSQDSKKKK KKKEKKKHKK 1740
HKKHKKHKKH AGADGDVEKS QKHKHKKKKA KKNKDKEKEK DDQKVRSVTV 1790 
Gene Ontology
 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0048568; P:embryonic organ development; IGI:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
 GO:0061053; P:somite development; IMP:MGI. 
Interpro
 IPR014891; DWNN_domain.
 IPR001878; Znf_CCHC.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF08783; DWNN
 PF00098; zf-CCHC 
SMART
 SM00184; RING
 SM00343; ZnF_C2HC 
PROSITE
 PS51282; DWNN
 PS50158; ZF_CCHC
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS