UniProt Accession

 ATP5H_HUMAN; O75947; B2R5L6; Q9H3J4 

Genbank Protein ID

 AF087135; AF070650; AF061735; AK312230; CH471099; BC032245; BC038092 

Genbank Nucleotide ID

 AAC36338.1; AAD20956.1; AAG43146.1; BAG35163.1; EAW89228.1; AAH32245.1; AAH38092.1 

Protein Name

 ATP synthase subunit d, mitochondrial 

Protein Synonyms/Alias

 ATPase subunit d 

Gene Name

 ATP5H 

Gene Synonyms/Alias

 My032 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
58	AIDWAYYKANVAKAG	ubiquitination	[1]
72	GLVDDFEKKVKSCAE	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 63 63 N6-acetyllysine (By similarity).
 MOD_RES 78 78 N6-acetyllysine (By similarity).
 MOD_RES 85 85 N6-acetyllysine.
 MOD_RES 95 95 N6-acetyllysine.
 MOD_RES 99 99 N6-acetyllysine (By similarity).
 MOD_RES 117 117 N6-acetyllysine.
 MOD_RES 149 149 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; CF(0); Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; IDA:UniProtKB.
 GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:InterPro.
 GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
 GO:0022857; F:transmembrane transporter activity; IC:UniProtKB.
 GO:0006200; P:ATP catabolic process; IDA:GOC.
 GO:0042776; P:mitochondrial ATP synthesis coupled proton transport; IC:UniProtKB.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome. 

Interpro

 IPR008689; ATPase_F0-cplx_dsu_mt. 

Pfam

 PF05873; Mt_ATP-synt_D 

SMART

  

PROSITE

  

PRINTS