UniProt Accession

 DHAS_BACSU; Q04797 

Genbank Protein ID

 L08471; AL009126; Z22554 

Genbank Nucleotide ID

 AAA22383.1; CAB13548.1; CAA80276.1 

Protein Name

 Aspartate-semialdehyde dehydrogenase 

Protein Synonyms/Alias

 ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase 

Gene Name

 asd 

Gene Synonyms/Alias

 BSU16750 

Created Date

 July 27, 2013 

Organism

 Bacillus subtilis (strain 168) 

NCBI Taxa ID

 224308 

Lysine Modification

Position	Peptide	Type	References
180	QTQAILNKEEIEPEI	acetylation	[1]

Reference

 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 

Functional Description

 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity). 

Sequence Annotation

 NP_BIND 13 16 NADP (By similarity).
 NP_BIND 41 42 NADP (By similarity).
 NP_BIND 160 161 NADP (By similarity).
 ACT_SITE 130 130 Acyl-thioester intermediate (By
 ACT_SITE 250 250 Proton acceptor (By similarity).
 BINDING 101 101 Phosphate (By similarity).
 BINDING 157 157 Substrate (By similarity).
 BINDING 221 221 Phosphate (By similarity).
 BINDING 243 243 Substrate (By similarity).
 BINDING 324 324 NADP (By similarity).
 MOD_RES 98 98 Phosphoserine.
 MOD_RES 146 146 Phosphotyrosine.  

Keyword

 Amino-acid biosynthesis; Complete proteome; Diaminopimelate biosynthesis; Lysine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Phosphoprotein; Reference proteome; Threonine biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0004073; F:aspartate-semialdehyde dehydrogenase activity; IEA:HAMAP.
 GO:0003942; F:N-acetyl-gamma-glutamyl-phosphate reductase activity; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:HAMAP.
 GO:0071266; P:'de novo' L-methionine biosynthetic process; IEA:HAMAP.
 GO:0019877; P:diaminopimelate biosynthetic process; IEA:HAMAP.
 GO:0009097; P:isoleucine biosynthetic process; IEA:InterPro.
 GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:HAMAP.
 GO:0009088; P:threonine biosynthetic process; IEA:HAMAP. 

Interpro

 IPR000319; Asp-semialdehyde_DH_CS.
 IPR012080; Asp_semialdehyde_DH.
 IPR005986; Asp_semialdehyde_DH_beta.
 IPR016040; NAD(P)-bd_dom.
 IPR000534; Semialdehyde_DH_NAD-bd.
 IPR012280; Semialdhyde_DH_dimer_dom. 

Pfam

 PF01118; Semialdhyde_dh
 PF02774; Semialdhyde_dhC 

SMART

 SM00859; Semialdhyde_dh 

PROSITE

 PS01103; ASD 

PRINTS