| Tag | Content |
|---|
| CPLM ID | CPLM-001943 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone H2A.1 |
Protein Synonyms/Alias | Histone H2A.2 |
Gene Name | HTA2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Tetrahymena pyriformis |
NCBI Taxa ID | 5908 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 6 | **MSTTGKGGKAKGK | acetylation | [1] | | 13 | KGGKAKGKTASSKQV | acetylation | [1] |
|
Reference | [1] Tetrahymena histone H2A. Acetylation in the N-terminal sequence and phosphorylation in the C-terminal sequence. Fusauchi Y, Iwai K. J Biochem. 1984 Jan;95(1):147-54. [ PMID: 6706903] |
Functional Description | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Sequence Annotation | MOD_RES 2 2 N-acetylserine.
MOD_RES 6 6 N6-acetyllysine.
MOD_RES 9 9 N6-acetyllysine (By similarity).
MOD_RES 11 11 N6-acetyllysine (By similarity).
MOD_RES 13 13 N6-acetyllysine.
MOD_RES 18 18 N6-acetyllysine (By similarity).
MOD_RES 123 123 Phosphoserine.
MOD_RES 129 129 Phosphoserine.
CROSSLNK 124 124 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Acetylation; Chromosome; Direct protein sequencing; DNA-binding; Isopeptide bond; Nucleosome core; Nucleus; Phosphoprotein; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 133 AA |
Protein Sequence | MSTTGKGGKA KGKTASSKQV SRSARAGLQF PVGRISRFLK NGRYSERIGT GAPVYLAAVL 60
EYLAAEVLEL AGNAAKDNKK TRIVPRHILL AIRNDEELNK LMANTTIADG GVLPNINPML 120
LPSKTKKTSE AEH 133 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |