UniProt Accession

 AHA1_YEAST; Q12449; D6VSJ8; Q02565; Q7LIE3 

Genbank Protein ID

 Z68194; Z68195; AY557694; U28414; BK006938 

Genbank Nucleotide ID

 CAA92357.1; CAA92365.1; AAS56020.1; AAA73862.1; DAA12058.1 

Protein Name

 Hsp90 co-chaperone AHA1 

Protein Synonyms/Alias

 Activator of Hsp90 ATPase protein 1 

Gene Name

 AHA1 

Gene Synonyms/Alias

 YDR214W; YD8142.16; YD8142B.06 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
186	DSASKPKKNALPSST	ubiquitination	[1]
254	QFFNSGPKLETKEKF	acetylation	[2]
254	QFFNSGPKLETKEKF	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Co-chaperone that binds to the molecular chaperone HSP82 and stimulates its ATPase activity. Binding to HSP82 promotes a conformational switch in the catalytic loop of HSP82, facilitating the interaction of the catalytic 'Arg-380' with ATP in the N- terminal nucleotide-binding domain. Although not essential, it confers thermotolerance when intracellular levels of HSP82 are limiting. 

Sequence Annotation

  

Keyword

 3D-structure; Chaperone; Complete proteome; Cytoplasm; Reference proteome; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 350 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IPI:SGD.
 GO:0001671; F:ATPase activator activity; IDA:UniProtKB.
 GO:0051087; F:chaperone binding; IDA:SGD.
 GO:0006457; P:protein folding; IMP:SGD.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 

Interpro

 IPR013538; Activator_of_Hsp90_ATPase.
 IPR015310; AHSA1_N.
 IPR023393; START-like_dom. 

Pfam

 PF09229; Aha1_N
 PF08327; AHSA1 

SMART

 SM01000; Aha1_N 

PROSITE

  

PRINTS