UniProt Accession

 TX1B3_HUMAN; O14907; B2RD53; D3DTJ6; Q7LCQ4 

Genbank Protein ID

 AF028823; AF168787; AF234997; AF277318; AK315408; CH471108; CH471108; BC023980 

Genbank Nucleotide ID

 AAB84248.2; AAF43104.1; AAG44368.1; AAK69111.1; BAG37800.1; EAW90491.1; EAW90492.1; AAH23980.1 

Protein Name

 Tax1-binding protein 3 

Protein Synonyms/Alias

 Glutaminase-interacting protein 3; Tax interaction protein 1; TIP-1; Tax-interacting protein 1 

Gene Name

 TAX1BP3 

Gene Synonyms/Alias

 TIP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
116	VTRQSLQKAVQQSML	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. 

Sequence Annotation

 DOMAIN 15 112 PDZ.
 MOD_RES 61 61 Phosphoserine.  

Keyword

 3D-structure; Cell membrane; Complete proteome; Cytoplasm; Membrane; Nucleus; Phosphoprotein; Reference proteome; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 124 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; NAS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0032864; P:activation of Cdc42 GTPase activity; IDA:BHF-UCL.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:2000009; P:negative regulation of protein localization to cell surface; IDA:UniProtKB.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; ISS:UniProtKB.
 GO:0007266; P:Rho protein signal transduction; IDA:UniProtKB.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR001478; PDZ.
 IPR017268; Tax1-binding_p3. 

Pfam

 PF00595; PDZ 

SMART

 SM00228; PDZ 

PROSITE

 PS50106; PDZ 

PRINTS