CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032023
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myotubularin 
Protein Synonyms/Alias
 cDNA FLJ50569, highly similar to Myotubularin (EC 3.1.3.48) 
Gene Name
 MTM1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MASASTSKYNSHSLEubiquitination[1]
20SLENESIKRTSRDGVubiquitination[1]
87RNLRFALKQEGHSRRubiquitination[1]
199SWIHPENKTVIVRCSubiquitination[1]
215PLVGMSGKRNKDDEKubiquitination[1]
222KRNKDDEKYLDVIREubiquitination[1]
509IRWNPRIKQQQPNPVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 566 AA 
Protein Sequence
MASASTSKYN SHSLENESIK RTSRDGVNRD LTEAVPRLPG ETLITDKEVI YICPFNGPIK 60
GRVYITNYRL YLRSLETDMR NLRFALKQEG HSRRDMFEIL TRYAFPLAHS LPLFAFLNEE 120
KFNVDGWTVY NPVEEYRRQG LPNHHWRITF INKCYELCDT YPALLVVPYR ASDDDLRRVA 180
TFRSRNRIPV LSWIHPENKT VIVRCSQPLV GMSGKRNKDD EKYLDVIRET NKQISKLTIY 240
DARPSVNAVA NKATGGGYES DDAYHNAELF FLDIHNIHVM RESLKKVKDI VYPNVEESHW 300
LSSLESTHWL EHIKLVLTGA IQVADKVSSG KSSVLVHCSD GWDRTAQLTS LAMLMLDSFY 360
RSIEGFEILV QKEWISFGHK FASRIGHGDK NHTDADRSPI FLQFIDCVWQ MSKQFPTAFE 420
FNEQFLIIIL DHLYSCRFGT FLFNCESARE RQKVTERTVS LWSLINSNKE KFKNPFYTKE 480
INRVLYPVAS MRHLELWVNY YIRWNPRIKQ QQPNPVEQRY MELLALRDEY IKRLEELQLA 540
NSAKLSDPPT SPSSPSQMMP HVQTHF 566 
Gene Ontology
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR004182; GRAM.
 IPR010569; Myotub-related.
 IPR017906; Myotubularin_phosphatase_dom.
 IPR011993; PH_like_dom.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS. 
Pfam
 PF02893; GRAM
 PF06602; Myotub-related 
SMART
 SM00568; GRAM 
PROSITE
 PS51339; PPASE_MYOTUBULARIN
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2 
PRINTS