CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015585
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase Nek10 
Protein Synonyms/Alias
 Never in mitosis A-related kinase 10; NimA-related protein kinase 10 
Gene Name
 NEK10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
42LLNVQSSKQQLPAINubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
 REPEAT 209 251 ARM.
 DOMAIN 519 712 Protein kinase.
 NP_BIND 525 533 ATP (By similarity).
 ACT_SITE 655 655 Proton acceptor (By similarity).
 BINDING 548 548 ATP (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1172 AA 
Protein Sequence
MPDQDKKVKT TEKSTDKQQE ITIRDYSDLK RLRCLLNVQS SKQQLPAINF DSAQNSMTKS 60
EPAIRAGGHR ARGQWHESTE AVELENFSIN YKNERNFSKH PQRKLFQEIF TALVKNRLIS 120
REWVNRAPSI HFLRVLICLR LLMRDPCYQE ILHSLGGIEN LAQYMEIVAN EYLGYGEEQH 180
TVDKLVNMTY IFQKLAAVKD QREWVTTSGA HKTLVNLLGA RDTNVLLGSL LALASLAESQ 240
ECREKISELN IVENLLMILH EYDLLSKRLT AELLRLLCAE PQVKEQVKLY EGIPVLLSLL 300
HSDHLKLLWS IVWILVQVCE DPETSVEIRI WGGIKQLLHI LQGDRNFVSD HSSIGSLSSA 360
NAAGRIQQLH LSEDLSPREI QENTFSLQAA CCAALTELVL NDTNAHQVVQ ENGVYTIAKL 420
ILPNKQKNAA KSNLLQCYAF RALRFLFSME RNRPLFKRLF PTDLFEIFID IGHYVRDISA 480
YEELVSKLNL LVEDELKQIA ENIESINQNK APLKYIGNYA ILDHLGSGAF GCVYKVRKHS 540
GQNLLAMKEV NLHNPAFGKD KKDRDSSVRN IVSELTIIKE QLYHPNIVRY YKTFLENDRL 600
YIVMELIEGA PLGEHFSSLK EKHHHFTEER LWKIFIQLCL ALRYLHKEKR IVHRDLTPNN 660
IMLGDKDKVT VTDFGLAKQK QENSKLTSVV GTILYSCPEV LKSEPYGEKA DVWAVGCILY 720
QMATLSPPFY STNMLSLATK IVEAVYEPVP EGIYSEKVTD TISRCLTPDA EARPDIVEVS 780
SMISDVMMKY LDNLSTSQLS LEKKLERERR RTQRYFMEAN RNTVTCHHEL AVLSHETFEK 840
ASLSSSSSGA ASLKSELSES ADLPPEGFQA SYGKDEDRAC DEILSDDNFN LENAEKDTYS 900
EVDDELDISD NSSSSSSSPL KESTFNILKR SFSASGGERQ SQTRDFTGGT GSRPRPALLP 960
LDLLLKVPPH MLRAHIKEIE AELVTGWQSH SLPAVILRNL KDHGPQMGTF LWQASAGIAV 1020
SQRKVRQISD PIQQILIQLH KIIYITQLPP ALHHNLKRRV IERFKKSLFS QQSNPCNLKS 1080
EIKKLSQGSP EPIEPNFFTA DYHLLHRSSG GNSLSPNDPT GLPTSIELEE GITYEQMQTV 1140
IEEVLEESGY YNFTSNRYHS YPWGTKNHPT KR 1172 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008266; Tyr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS50176; ARM_REPEAT
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS