UniProt Accession

 SEH1_YEAST; P53011; D6VU45 

Genbank Protein ID

 X90994; Z72622; AY558497; BK006941 

Genbank Nucleotide ID

 CAA62480.1; CAA96806.1; AAS56823.1; DAA08006.1 

Protein Name

 Nucleoporin SEH1 

Protein Synonyms/Alias

 Nuclear pore protein SEH1; SEC13 homolog 1 

Gene Name

 SEH1 

Gene Synonyms/Alias

 YGL100W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
100	CSGRRWNKLCTLNDS	ubiquitination	[1]
108	LCTLNDSKGSLYSVK	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Involved in nuclear poly(A)+ RNA export and NPC biogenesis. It is also required for normal nuclear morphology. Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. 

Sequence Annotation

 REPEAT 7 46 WD 1.
 REPEAT 53 94 WD 2.
 REPEAT 106 147 WD 3.
 REPEAT 153 192 WD 4.
 REPEAT 210 253 WD 5.
 REPEAT 302 341 WD 6.
 MOD_RES 257 257 Phosphoserine.  

Keyword

 3D-structure; Cell membrane; Complete proteome; Direct protein sequencing; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Repeat; Translocation; Transport; Vacuole; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 349 AA 

Protein Sequence

Gene Ontology

 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0031080; C:nuclear pore outer ring; IDA:SGD.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0035859; C:Seh1-associated complex; IDA:SGD.
 GO:0017056; F:structural constituent of nuclear pore; IC:SGD.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0006913; P:nucleocytoplasmic transport; IC:SGD.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS