UniProt Accession

 PRS8_MOUSE; P62196; O35051; P47210; P52915; P52916; Q3UL51; Q9CWN5 

Genbank Protein ID

 Z54219; AK010505; AK135451; AK145703 

Genbank Nucleotide ID

 CAA90961.1; BAB26990.1; BAE22539.1; BAE26599.1 

Protein Name

 26S protease regulatory subunit 8 

Protein Synonyms/Alias

 26S proteasome AAA-ATPase subunit RPT6; Proteasome 26S subunit ATPase 5; Proteasome subunit p45; p45/SUG; mSUG1 

Gene Name

 Psmc5 

Gene Synonyms/Alias

 Sug1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
38	LQLIVNDKSQNLRRL	ubiquitination	[1]
88	DKKKVLVKVHPEGKF	ubiquitination	[1]
94	VKVHPEGKFVVDVDK	acetylation	[2]
101	KFVVDVDKNIDINDV	ubiquitination	[1]
125	NDSYTLHKILPNKVD	ubiquitination	[1]
170	EVIELPVKHPELFEA	ubiquitination	[1]
196	YGPPGTGKTLLARAV	ubiquitination	[1]
222	SGSELVQKFIGEGAR	acetylation	[2, 3]
222	SGSELVQKFIGEGAR	ubiquitination	[1]
287	LDGFEATKNIKVIMA	ubiquitination	[1]
330	EARLDILKIHSRKMN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. 

Sequence Annotation

 NP_BIND 190 197 ATP (Potential).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 222 222 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Nucleotide-binding; Nucleus; Proteasome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005675; C:holo TFIIH complex; ISA:MGI.
 GO:0031595; C:nuclear proteasome complex; IEA:Compara.
 GO:0022624; C:proteasome accessory complex; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:Compara.
 GO:0031531; F:thyrotropin-releasing hormone receptor binding; ISS:UniProtKB.
 GO:0008134; F:transcription factor binding; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. 

Interpro

 IPR005937; 26S_Psome_P45.
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00004; AAA 

SMART

 SM00382; AAA 

PROSITE

 PS00674; AAA 

PRINTS