CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020392
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family A member 2 
Protein Synonyms/Alias
 ATP-binding cassette transporter 2; ATP-binding cassette 2 
Gene Name
 ABCA2 
Gene Synonyms/Alias
 ABC2; KIAA1062 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1222GYRLTLVKRPAEPGGubiquitination[1]
1336ENSEADVKESRKDVLubiquitination[1]
1704ITFGNVLKSIPASFGubiquitination[2]
2025QRMPVSTKPVEDDVDubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. 
Sequence Annotation
 DOMAIN 990 1221 ABC transporter 1.
 DOMAIN 2050 2285 ABC transporter 2.
 NP_BIND 1024 1031 ATP 1 (Potential).
 NP_BIND 2087 2094 ATP 2 (Potential).
 MOD_RES 1327 1327 Phosphoserine.
 MOD_RES 1331 1331 Phosphoserine.
 MOD_RES 2412 2412 Phosphothreonine.
 CARBOHYD 14 14 N-linked (GlcNAc...) (Potential).
 CARBOHYD 89 89 N-linked (GlcNAc...) (Potential).
 CARBOHYD 168 168 N-linked (GlcNAc...) (Potential).
 CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
 CARBOHYD 305 305 N-linked (GlcNAc...) (Potential).
 CARBOHYD 368 368 N-linked (GlcNAc...) (Potential).
 CARBOHYD 379 379 N-linked (GlcNAc...) (Potential).
 CARBOHYD 420 420 N-linked (GlcNAc...) (Potential).
 CARBOHYD 432 432 N-linked (GlcNAc...) (Potential).
 CARBOHYD 476 476 N-linked (GlcNAc...) (Potential).
 CARBOHYD 484 484 N-linked (GlcNAc...) (Potential).
 CARBOHYD 494 494 N-linked (GlcNAc...) (Potential).
 CARBOHYD 530 530 N-linked (GlcNAc...) (Potential).
 CARBOHYD 544 544 N-linked (GlcNAc...) (Potential).
 CARBOHYD 590 590 N-linked (GlcNAc...) (Potential).
 CARBOHYD 600 600 N-linked (GlcNAc...) (Potential).
 CARBOHYD 628 628 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1408 1408 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1496 1496 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1549 1549 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1557 1557 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1612 1612 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1677 1677 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1775 1775 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2054 2054 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Endosome; Glycoprotein; Lysosome; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2435 AA 
Protein Sequence
MGFLHQLQLL LWKNVTLKRR SPWVLAFEIF IPLVLFFILL GLRQKKPTIS VKEAFYTAAP 60
LTSAGILPVM QSLCPDGQRD EFGFLQYANS TVTQLLERLD RVVEEGNLFD PARPSLGSEL 120
EALRQHLEAL SAGPGTSGSH LDRSTVSSFS LDSVARNPQE LWRFLTQNLS LPNSTAQALL 180
AARVDPPEVY HLLFGPSSAL DSQSGLHKGQ EPWSRLGGNP LFRMEELLLA PALLEQLTCT 240
PGSGELGRIL TVPESQKGAL QGYRDAVCSG QAAARARRFS GLSAELRNQL DVAKVSQQLG 300
LDAPNGSDSS PQAPPPRRLQ ALLGDLLDAQ KVLQDVDVLS ALALLLPQGA CTGRTPGPPA 360
SGAGGAANGT GAGAVMGPNA TAEEGAPSAA ALATPDTLQG QCSAFVQLWA GLQPILCGNN 420
RTIEPEALRR GNMSSLGFTS KEQRNLGLLV HLMTSNPKIL YAPAGSEVDR VILKANETFA 480
FVGNVTHYAQ VWLNISAEIR SFLEQGRLQQ HLRWLQQYVA ELRLHPEALN LSLDELPPAL 540
RQDNFSLPSG MALLQQLDTI DNAACGWIQF MSKVSVDIFK GFHDEESIVN YTLNQAYQDN 600
VTVFASVIFQ TRKDGSLPPH VHYKIRQNSS FTEKTNEIRR AYWRPGPNTG GRFYFLYGFV 660
WIQDMMERAI IDTFVGHDVV EPGSYVQMFP YPCYTRDDFL FVIEHMMPLC MVISWVYSVA 720
MTIQHIVAEK EHRLKEVMKT MGLNNAVHWV AWFITGFVQL SISVTALTAI LKYGQVLMHS 780
HVVIIWLFLA VYAVATIMFC FLVSVLYSKA KLASACGGII YFLSYVPYMY VAIREEVAHD 840
KITAFEKCIA SLMSTTAFGL GSKYFALYEV AGVGIQWHTF SQSPVEGDDF NLLLAVTMLM 900
VDAVVYGILT WYIEAVHPGM YGLPRPWYFP LQKSYWLGSG RTEAWEWSWP WARTPRLSVM 960
EEDQACAMES RRFEETRGME EEPTHLPLVV CVDKLTKVYK DDKKLALNKL SLNLYENQVV 1020
SFLGHNGAGK TTTMSILTGL FPPTSGSATI YGHDIRTEMD EIRKNLGMCP QHNVLFDRLT 1080
VEEHLWFYSR LKSMAQEEIR REMDKMIEDL ELSNKRHSLV QTLSGGMKRK LSVAIAFVGG 1140
SRAIILDEPT AGVDPYARRA IWDLILKYKP GRTILLSTHH MDEADLLGDR IAIISHGKLK 1200
CCGSPLFLKG TYGDGYRLTL VKRPAEPGGP QEPGLASSPP GRAPLSSCSE LQVSQFIRKH 1260
VASCLLVSDT STELSYILPS EAAKKGAFER LFQHLERSLD ALHLSSFGLM DTTLEEVFLK 1320
VSEEDQSLEN SEADVKESRK DVLPGAEGPA SGEGHAGNLA RCSELTQSQA SLQSASSVGS 1380
ARGDEGAGYT DVYGDYRPLF DNPQDPDNVS LQEVEAEALS RVGQGSRKLD GGWLKVRQFH 1440
GLLVKRFHCA RRNSKALFSQ ILLPAFFVCV AMTVALSVPE IGDLPPLVLS PSQYHNYTQP 1500
RGNFIPYANE ERREYRLRLS PDASPQQLVS TFRLPSGVGA TCVLKSPANG SLGPTLNLSS 1560
GESRLLAARF FDSMCLESFT QGLPLSNFVP PPPSPAPSDS PASPDEDLQA WNVSLPPTAG 1620
PEMWTSAPSL PRLVREPVRC TCSAQGTGFS CPSSVGGHPP QMRVVTGDIL TDITGHNVSE 1680
YLLFTSDRFR LHRYGAITFG NVLKSIPASF GTRAPPMVRK IAVRRAAQVF YNNKGYHSMP 1740
TYLNSLNNAI LRANLPKSKG NPAAYGITVT NHPMNKTSAS LSLDYLLQGT DVVIAIFIIV 1800
AMSFVPASFV VFLVAEKSTK AKHLQFVSGC NPIIYWLANY VWDMLNYLVP ATCCVIILFV 1860
FDLPAYTSPT NFPAVLSLFL LYGWSITPIM YPASFWFEVP SSAYVFLIVI NLFIGITATV 1920
ATFLLQLFEH DKDLKVVNSY LKSCFLIFPN YNLGHGLMEM AYNEYINEYY AKIGQFDKMK 1980
SPFEWDIVTR GLVAMAVEGV VGFLLTIMCQ YNFLRRPQRM PVSTKPVEDD VDVASERQRV 2040
LRGDADNDMV KIENLTKVYK SRKIGRILAV DRLCLGVRPG ECFGLLGVNG AGKTSTFKML 2100
TGDESTTGGE AFVNGHSVLK ELLQVQQSLG YCPQCDALFD ELTAREHLQL YTRLRGISWK 2160
DEARVVKWAL EKLELTKYAD KPAGTYSGGN KRKLSTAIAL IGYPAFIFLD EPTTGMDPKA 2220
RRFLWNLILD LIKTGRSVVL TSHSMEECEA LCTRLAIMVN GRLRCLGSIQ HLKNRFGDGY 2280
MITVRTKSSQ SVKDVVRFFN RNFPEAMLKE RHHTKVQYQL KSEHISLAQV FSKMEQVSGV 2340
LGIEDYSVSQ TTLDNVFVNF AKKQSDNLEQ QETEPPSALQ SPLGCLLSLL RPRSAPTELR 2400
ALVADEPEDL DTEDEGLISF EEERAQLSFN TDTLC 2435 
Gene Ontology
 GO:0043190; C:ATP-binding cassette (ABC) transporter complex; NAS:UniProtKB.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; ISS:UniProtKB.
 GO:0005768; C:endosome; IDA:UniProtKB.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IDA:UniProtKB.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0005815; C:microtubule organizing center; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; NAS:UniProtKB.
 GO:0042632; P:cholesterol homeostasis; IEP:UniProtKB.
 GO:0006629; P:lipid metabolic process; NAS:UniProtKB.
 GO:0032383; P:regulation of intracellular cholesterol transport; IMP:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0042493; P:response to drug; TAS:UniProtKB.
 GO:0048545; P:response to steroid hormone stimulus; IEP:UniProtKB. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026082; ABC_A.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS