CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010109
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Peptide chain release factor 1 
Protein Synonyms/Alias
 RF-1 
Gene Name
 prfA 
Gene Synonyms/Alias
 MPN_361; MP475 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
36DLTFEQIKAINKELKacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity). 
Sequence Annotation
 MOD_RES 236 236 N5-methylglutamine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Methylation; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 359 AA 
Protein Sequence
MEFDKQFFSS VEKIVELAEQ LEKDLNKPDL TFEQIKAINK ELKHKQPLVV KFKEFKRLID 60
QALEAEAILE NNELKELHDE AKKELERVRS VVPEYEEALK LLLLPIDENN QKNVIVELRP 120
AAGGDESCIF LADLFNMYRN FCSNKGWKLQ INEMIPSSVG LNFVSFEVNG VDVFAKLKFE 180
SGVHRVQRVP ATESKGRVHT STVTVAVLPQ LEAVEVHINP ADLRVDTYRA SGAGGQHVNR 240
TESAVRITHL PTGIVVSCQE GKSQFTNRDT AMKMLRAKLW EKAQNEQLST QAGLRKSQVG 300
SGDRAEKIRT YNYPQNRVTD HRIKLTVNKL NTIILGDLDE IIEALQADEK KQQLENFFS 359 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016149; F:translation release factor activity, codon specific; IEA:HAMAP. 
Interpro
 IPR014720; dsRNA-bd-like_dom.
 IPR005139; PCRF.
 IPR000352; Pep_chain_release_fac_I_II.
 IPR004373; PrfA. 
Pfam
 PF03462; PCRF
 PF00472; RF-1 
SMART
 SM00937; PCRF 
PROSITE
 PS00745; RF_PROK_I 
PRINTS