CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028988
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DKFZP586J0619 protein 
Protein Synonyms/Alias
 Integrator complex subunit 1 
Gene Name
 DKFZP586J0619 
Gene Synonyms/Alias
 INTS1; tcag7.531 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
175KTASTLLKPAPSGLPacetylation[1, 2, 3, 4]
228AEAAVAEKRAISPSIacetylation[4]
433ELLIAEEKLSPEQEGubiquitination[5]
697IAWDKGEKRNLEVLRubiquitination[6]
809ELADHLVKRAAAVQAubiquitination[5, 6]
823ADDVEVLKVGRTQLIubiquitination[5, 6, 7, 8]
997PHILDQVKSLNQSLRubiquitination[5]
1171SLRDGEEKEPPMEEDubiquitination[5, 8]
1297VRRMRQSKEGEEVYSubiquitination[5]
1522RDSTEAPKPKSSPEQubiquitination[4, 6]
1524STEAPKPKSSPEQPIubiquitination[4, 5, 6, 7]
1742VEPDLISKVLQGLIEubiquitination[5]
2038AASSSVCKLDGLIHRubiquitination[4, 6, 7]
2072DASMACRKLAVAHPLubiquitination[6, 7, 9]
2256AEMAPYMKRLSRGQTubiquitination[8]
Reference
 [1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [8] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [9] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2394 AA 
Protein Sequence
MWLSGKSQVQ KRGAVRYLQA PPVNGEASAC PAPPTHLDRT TCARRRPARL PPPWGAAGIR 60
PAPRASRASF WARFPPHCFP SGCSGSRVLE GGEIGFRFRG GRVAAAALRS RWARGDAAAA 120
GSREGRGRMN RAKPTTVRRP SAAAKPSGHP PPGDFIALGS KGQANESKTA STLLKPAPSG 180
LPSERKRDAA AALSSASALT GLTKRPKLSS TPPLSALGRL AEAAVAEKRA ISPSIKEPSV 240
VPIEVLPTVL LDEIEAAELE GNDDRIEGVL CGAVKQLKVT RAKPDSTLYL SLMYLAKIKP 300
NIFATEGVIE ALCSLLRRDA SINFKAKGNS LVSVLACNLL MAAYEEDENW PEIFVKVYIE 360
DSLGERIWVD SPHCKTFVDN IQTAFNTRMP PRSVLLQGEA GRVAGDLGAG SSPHPSLTEE 420
EDSQTELLIA EEKLSPEQEG QLMPRYEELA ESVEEYVLDM LRDQLNRRQP IDNVSRNLLR 480
LLTSTCGYKE VRLLAVQKLE MWLQNPKLTR PAQDLLMSVC MNCNTHGSED MDVISHLIKI 540
RLKPKVLLNH FMLCIRELLS AHKDNLGTTI KLVIFNELSS ARNPNNMQVL YTALQHSSEL 600
APKFLAMVFQ DLLTNKDDYL RASRALLREI IKQTKHEINF QAFCLGLMQE RKEPQYLEME 660
FKERFVVHIT DVLAVSMMLG ITAQVKEAGI AWDKGEKRNL EVLRSFQNQI AAIQRDAVWW 720
LHTVVPSISK LAPKDYVHCL HKVLFTEQPE TYYKWDNWPP ESDRNFFLRL CSEVPILEDT 780
LMRILVIGLS RELPLGPADA MELADHLVKR AAAVQADDVE VLKVGRTQLI DAVLNLCTYH 840
HPENIQLPPG YQPPNLAIST LYWKAWPLLL VVAAFNPENI GLAAWEEYPT LKMLMEMVMT 900
NNYSYPPCTL TDEETRTEML NRELQTAQRE KQEILAFEGH LAAASTKQTI TESSSLLLSQ 960
LTSLDPQYAA HTAPPCACRR DLGPPRRPPP HILDQVKSLN QSLRLGHLLC RSRNPDFLLH 1020
IIQRQASSQS MPWLADLVQS SEGSLDVLPV QCLCEFLLHD AVDDAASGEE DDEGESKEQK 1080
AKKRQRQQKQ RQLLGRLQDL LLGPKADEQT TCEVLDYFLR RLGSSQVASR VLAMKGETLP 1140
ALPKAGPAHE CLPQGLSLVL SEGSLRDGEE KEPPMEEDVG DTDVLQGYQW LLRDLPRLPL 1200
FDSVRSTTAL ALQQAIHMET DPQTISAYLI YLSQHTPVEE QAQHSDLALD VARLVVERST 1260
IMSHLFSKLS PSAASDAVLS ALLSIFSRYV RRMRQSKEGE EVYSWSESQD QVFLRWSSGE 1320
TATMHILVVH AMVILLTLGP PRADDSEFQA LLDIWFPEEK PLPTAFLVDT SEEALLLPDW 1380
LKLRMIRSEV LRLVDAALQD LEPQQLLLFV QSFGIPVSSM SKLLQFLDQA VAHDPQTLEQ 1440
NIMDKSKMPG TCGVGSHTLT EPQPGQAFGA WVRAGVTLLR FADYMAHLVE VQHERGASGG 1500
QTFHSLLTAS LPPRRDSTEA PKPKSSPEQP IGQGRIRVGT QLRVLGPEDD LAGMFLQIFP 1560
LSPDPRWQSS SPRPVALALQ QALGQELARV VQGSPEVPGI TVRVLQALAT LLSSPHGGAL 1620
VMSMHRSHFL ACPLLRQLCQ YQRCVPQDTG FSSLFLKVLL QMLQWLDSPG VEGGPLRAQL 1680
RMLASQASAG RRLSDVRGGL LRLAEALAFR QDLEVVSSTV RAVIATLRSG EQCSVEPDLI 1740
SKVLQGLIEV RSPHLEELLT AFFSATADAA SPFPACKPVV VVSSLLLQEE EPLAGGKPGA 1800
DGGSLEAVRL GPSSGLLVDW LEMLDPEVVS SCPDLQLRLL FSRRKGKGQA QVPSFRPYLL 1860
TLFTHQSSWP TLHQCIRVLL GKSREQRFDP SASLDFLWAC IHVPRIWQGR DQRTPQAGLG 1920
RKRREELVLR VQGPELISLV ELILAEAETR SQDGDTAACS LIQARLPLLL SCCCGDDESV 1980
RKVTEHLSGC IQQWGDSVLG RRCRDLLLQL YLQRPELRVP VPEVLLHSEG AASSSVCKLD 2040
GLIHRFITLL ADTSDSRALE NRGADASMAC RKLAVAHPLL LLRHLPMIAA LLHGRTHLNF 2100
QEFRQQNHLS CFLHVLGLLE LLQPHVFRSE HQGALWDCLL SFIRLLLNYR KSSRHLAAFI 2160
NKFVQFIHKY ITYNAPAAIS FLQKHADPLH DLSFDNSDLV MLKSLLAGLS LPSRDDRTDR 2220
GLDEEGEEES SAGSLPLVSV SLFTPLTAAE MAPYMKRLSR GQTVEDLLEV LSDIDEMSRR 2280
RPEILSFFST NLQRLMSSAE ECCRNLAFSL ALRSMQNSPS IAAAFLPTFM YCLGSQDFEV 2340
VQTALRNLPE YALLCQEHAA VLLHRAFLVG MYGQMDPSAQ ISEALRILHM EAVM 2394 
Gene Ontology
  
Interpro
 IPR022145; DUF3677. 
Pfam
 PF12432; DUF3677 
SMART
  
PROSITE
  
PRINTS