UniProt Accession

 TSPO_MOUSE; P50637; Q62118; Q6LCZ0 

Genbank Protein ID

 L17306; D21207; U12419 

Genbank Nucleotide ID

 AAA20127.1; BAA04749.1; AAA83253.1 

Protein Name

 Translocator protein 

Protein Synonyms/Alias

 Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR 

Gene Name

 Tspo 

Gene Synonyms/Alias

 Bzrp; Mbr 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
39	RWYASLQKPSWHPPR	acetylation	[1]
39	RWYASLQKPSWHPPR	succinylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme (By similarity). Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Mitochondrion; Receptor; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 169 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005497; F:androgen binding; IEA:Compara.
 GO:0008503; F:benzodiazepine receptor activity; IEA:Compara.
 GO:0030325; P:adrenal gland development; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0048266; P:behavioral response to pain; IEA:Compara.
 GO:0071476; P:cellular hypotonic response; IEA:Compara.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0071294; P:cellular response to zinc ion; IEA:Compara.
 GO:0060242; P:contact inhibition; IEA:Compara.
 GO:0008347; P:glial cell migration; IEA:Compara.
 GO:0060253; P:negative regulation of glial cell proliferation; IEA:Compara.
 GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IEA:Compara.
 GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Compara.
 GO:0014012; P:peripheral nervous system axon regeneration; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0051928; P:positive regulation of calcium ion transport; IEA:Compara.
 GO:0060252; P:positive regulation of glial cell proliferation; IEA:Compara.
 GO:0051901; P:positive regulation of mitochondrial depolarization; IEA:Compara.
 GO:0010940; P:positive regulation of necrotic cell death; IEA:Compara.
 GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Compara.
 GO:0050810; P:regulation of steroid biosynthetic process; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0010042; P:response to manganese ion; IEA:Compara.
 GO:0032570; P:response to progesterone stimulus; IEA:Compara.
 GO:0033574; P:response to testosterone stimulus; IEA:Compara.
 GO:0010266; P:response to vitamin B1; IEA:Compara.
 GO:0006694; P:steroid biosynthetic process; IEA:Compara. 

Interpro

 IPR004307; TspO_MBR. 

Pfam

 PF03073; TspO_MBR 

SMART

  

PROSITE

  

PRINTS