CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009239
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP phosphoribosyltransferase 
Protein Synonyms/Alias
 ATP-PRT; ATP-PRTase 
Gene Name
 hisG 
Gene Synonyms/Alias
 b2019; JW2001 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
125GPLSLNGKRIATSYPacetylation[1]
136TSYPHLLKRYLDQKGacetylation[1]
142LKRYLDQKGISFKSCacetylation[1]
147DQKGISFKSCLLNGSacetylation[1]
206DGEMEESKQQLIDKLacetylation[1]
212SKQQLIDKLLTRIQGacetylation[1]
227VIQARESKYIMMHAPacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity). 
Sequence Annotation
  
Keyword
 3D-structure; Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm; Glycosyltransferase; Histidine biosynthesis; Magnesium; Metal-binding; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 299 AA 
Protein Sequence
MTDNTRLRIA MQKSGRLSDD SRELLARCGI KINLHTQRLI AMAENMPIDI LRVRDDDIPG 60
LVMDGVVDLG IIGENVLEEE LLNRRAQGED PRYFTLRRLD FGGCRLSLAT PVDEAWDGPL 120
SLNGKRIATS YPHLLKRYLD QKGISFKSCL LNGSVEVAPR AGLADAICDL VSTGATLEAN 180
GLREVEVIYR SKACLIQRDG EMEESKQQLI DKLLTRIQGV IQARESKYIM MHAPTERLDE 240
VIALLPGAER PTILPLAGDQ QRVAMHMVSS ETLFWETMEK LKALGASSIL VLPIEKMME 299 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003879; F:ATP phosphoribosyltransferase activity; IDA:EcoCyc.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0000105; P:histidine biosynthetic process; IDA:EcoCyc. 
Interpro
 IPR013820; ATP_PRibTrfase_cat.
 IPR018198; ATP_PRibTrfase_CS.
 IPR001348; ATP_PRibTrfase_HisG.
 IPR020621; ATP_PRibTrfase_HisG_long.
 IPR013115; HisG_C.
 IPR011322; N-reg_PII-like_a/b.
 IPR015867; N-reg_PII/ATP_PRibTrfase_C. 
Pfam
 PF01634; HisG
 PF08029; HisG_C 
SMART
  
PROSITE
 PS01316; ATP_P_PHORIBOSYLTR 
PRINTS