| Tag | Content |
|---|
| CPLM ID | CPLM-015573 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DENN domain-containing protein 5B |
Protein Synonyms/Alias | Rab6IP1-like protein |
Gene Name | DENND5B |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 543 | EQMQNFDKASFLSDQ | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. |
Sequence Annotation | DOMAIN 50 120 UDENN.
DOMAIN 187 375 DENN.
DOMAIN 498 574 dDENN.
DOMAIN 772 932 RUN 1.
DOMAIN 936 1044 PLAT.
DOMAIN 1118 1267 RUN 2.
MOD_RES 2 2 N-acetylserine.
MOD_RES 1076 1076 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1274 AA |
Protein Sequence | MSGSCAAPGP GSGSSPAACR FAHYFVLCGI DADSGLEPDE LAGENFDQSP LRRTFKSKVL 60
AHYPQNIEWN PFDQDAVNML CMPKGLSFRT QTDNKDPQFH SFIITREDGS RTYGFVLTFY 120
EEVTSKQICT AMQTLYQMHN AEHYSSVYAS SSCSMDSLAS SLDEGDTTSL LKLQRYNSYD 180
ISRDTLYVSK SICLITPLPF MQACKKFLIQ LYKAVTSQQP PPLPLESYIH NILYEVPLPP 240
PGRSLKFYGV YEPVICQRPG PSELPLSDYP LREAFELLGL ENLVQVFTCV LLEMQILLYS 300
QDYQRLMTVA EGITTLLFPF QWQHVYVPIL PASLLHFLDA PVPYLMGLQS KEGTDRSKLE 360
LPQEANLCFV DIDNHFIELP EEFPQFPNKV DFIQELSEVL VQFGIPPEGS LHCSESTSKL 420
KNMVLKDLVN DKKNGNVCTN NISMYELLKG NETIARLQAL AKRTGVAVEK MDLSASLGEK 480
DKDLKLHCEE AELRDYQLNV QLREVFANRF TQMFADYEAF VIQTAQDMES WLTNREQMQN 540
FDKASFLSDQ PEPYLPFLSR FIETQMFATF IDNKIMSQWE EKDPLLRVFD TRIDKIRLYN 600
VRAPTLRTSI YQKCSTLKEA AQSIEQRLMK MDHTAIHPHL LDMKIGQGKY EQGFFPKLQS 660
DVLATGPTSN NRWVSRSATA QRRKERLRQH SEHVGLDNDL REKYMQEARS LGKNLRQPKL 720
SDLSPAVIAQ TNCKFVEGLL KECRMKTKRM LVEKMGHEAV ELGHGEANIT GLEENTLIAS 780
LCDLLERIWS HGLQVKQGKS ALWSHLIQFQ DREEKQEHLA ESPVALGPER RKSDSGVMLP 840
TLRVSLIQDM RHIQNMSEIK TDVGRARAWI RLSLEKKLLS QHLKQLLSNQ PLTKKLYKRY 900
AFLRCEEERE QFLYHLLSLN AVDYFCFTSV FTTIMIPYRS VIIPIKKLSN AIITSNPWIC 960
VSGELGDTGV MQIPKNLLEM TFECQNLGKL TTVQIGHDNS GLLAKWLVDC VMVRNEITGH 1020
TYRFPCGRWL GKGIDDGSLE RILIGELMTS ASDEDLVKQC RTPPQQKSPT TARRLSITSL 1080
TGKNNKPNAG QIQEGIGEAV NNIVKHFHKP EKERGSLTVL LCGENGLVAA LEQVFHHGFK 1140
SARIFHKNVF IWDFIEKVVA YFETTDQILD NEDDVLIQKS SCKTFCHYVN AINTAPRNIG 1200
KDGKFQILVC LGTRDRLLPQ WIPLLAECPA ITRMYEESAL LRDRMTVNSL IRILQTIQDF 1260
TIVLEGSLIK GVDV 1274 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016020; C:membrane; IBA:RefGenome. GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |