CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013007
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2',5'-phosphodiesterase 12 
Protein Synonyms/Alias
 2'-PDE; 2-PDE 
Gene Name
 Pde12 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
426LNPLAQEKVLQRSSVacetylation[1]
426LNPLAQEKVLQRSSVubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferon (IFNs) (By similarity). 
Sequence Annotation
 MOD_RES 216 216 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Hydrolase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 608 AA 
Protein Sequence
MWRLPGRSAL RGVRSVVERR SRAEAGTHEA VRAMERAVVR CVPSEPKLSL SFALADGSHK 60
NMQRDQSEPL GRALSRIATN ALKGHAKVAA AKKSRKNRAH SSGGAACEAT GPEPVATCEP 120
VVKLYYREEA VAEDVLNVDA WQDGAVLQIG DVKYKVERNP PTFTELQLPR YIMAGFPVCP 180
KLGVEFGDPA SSVFRWYKEV KPGAAEPGDS GPASSSHSSQ PSAWIETGVD ERVYTPCNAD 240
IGLRLRLHCT PGNGQRFGPS RELESLCPVE AGPGTCTFDH RHLYTKKVTE DSFIRTVSYN 300
ILADTYAQTE FSRTVLYPYC APYALELDYR QNLIQKELTG YNADLICLQE VDRAVFSDSL 360
VPALEAFGLE GVFRIKQHEG LATFYRKSKF RLLSQHDISF QEALKSDPLH KELLEKLALN 420
PLAQEKVLQR SSVLQISVLQ STTDSSKKIC VANTHLYWHP KGGYIRLIQM EVALVHIRHV 480
SRDLYPGIPV IFCGDFNSTP STGMYHFVIS GSIAEDHEDW ASNGEEERCS MPLSHCFKLK 540
SACGEPAYTN YVGGFHGCLD YIFIDLNTLE VEQVIPLPSH EEVTTHQALP SVSHPSDHIA 600
LVCDLKWK 608 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. 
Interpro
 IPR005135; Endo/exonuclease/phosphatase. 
Pfam
 PF03372; Exo_endo_phos 
SMART
  
PROSITE
  
PRINTS