CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038364
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 H(+)/Cl(-) exchange transporter 3 
Protein Synonyms/Alias
  
Gene Name
 Clcn3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
25IPLRELHKRGTHYTMubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 839 AA 
Protein Sequence
MDASSDPYLP YDGGGDSIPL RELHKRGTHY TMTNGGSINS STHLLDLLDE PIPGVGTYDD 60
FHTIDWVREK CKDRERHRRI NSKKKESAWE MTKSLYDAWS GWLVVTLTGL ASGALAGLID 120
IAADWMTDLK EGICLSALWY NHEQCCWGSN ETTFEERDKC PQWKTWAELI IGQAEGPGSY 180
IMNYIMYIFW ALSFAFLAVS LVKVFAPYAC GSGIPEIKTI LSGFIIRGYL GKWTLMIKTI 240
TLVLAVASGL SLGKEGPLVH VACCCGNIFS YLFPKYSTNE AKKREVLSAA SAAGVSVAFG 300
APIGGVLFSL EEVSYYFPLK TLWRSFFAAL VAAFVLRSIN PFGNSRLVLF YVEYHTPWYL 360
FELFPFILLG VFGGLWGAFF IRANIAWCRR RKSTKFGKYP VLEVIIVAAI TAVIAFPNPY 420
TRLNTSELIK ELFTDCGPLE SSSLCDYRND MNASKIVDDI PDRPAGVGVY SAIWQLCLAL 480
IFKIIMTVFT FGIKVPSGLF IPSMAIGAIA GRIVGIAVEQ LAYYHHDWFI FKEWCEVGAD 540
CITPGLYAMV GAAACLGGVT RMTVSLVVIV FELTGGLEYI VPLMAAVMTS KWVGDAFGRE 600
GIYEAHIRLN GYPFLDAKEE FTHTTLAADV MRPRRSDPPL AVLTQDNMTV DDIENMINET 660
SYNGFPVIMS KESQRLVGFA LRRDLTIAIE SARKKQEGIV GSSRVCFAQH TPSLPAESPR 720
PLKLRSILDM SPFTVTDHTP MEIVVDIFRK LGLRQCLVTH NGIVLGIITK KNILEHLEQL 780
KQHVEPLTPP WHYNKKRYPP SYGPDGKPRP RFNNVQLSPV DEDREETEEE VRLLNSTIL 839 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro. 
Interpro
 IPR014743; Cl-channel_core.
 IPR001807; Cl-channel_volt-gated.
 IPR002245; Cl_channel-3.
 IPR000644; Cysta_beta_synth_core. 
Pfam
 PF00571; CBS
 PF00654; Voltage_CLC 
SMART
 SM00116; CBS 
PROSITE
 PS51371; CBS 
PRINTS
 PR00762; CLCHANNEL.
 PR01114; CLCHANNEL3.