CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031527
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pumilio homolog 2 
Protein Synonyms/Alias
 cDNA FLJ53521, highly similar to Pumilio homolog 2 
Gene Name
 PUM2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
540STSSDLYKRSSSSLAubiquitination[1, 2, 3]
691GSRFIQQKLERATPAubiquitination[2]
762YGCRVIQKALESISSubiquitination[3]
906FASNVVEKCVTHASRubiquitination[1]
988HILAKLEKYYLKNSPubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1008 AA 
Protein Sequence
MSQPIMVQRR SGQGFHGNSE VNAILSPRSE SGGLGVSMVE YVLSSSPADK LDSRFRKGNF 60
GTRDAETDGP EKGDQKGKAS PFEEDQNRDL KQGDDDDSKI NGRGLPNGMD ADCKDFNRTP 120
GSRQASPTEV VERLGPNTNP SEGLGPLPNP TANKPLVEEF SNPETQNLDA MEQVGLESLQ 180
FDYPGNQVPM DSSGATVGLF DYNSQQQLFQ RTNALTVQQL TAAQQQQYAL AAAQQPHIAG 240
VFSAGLAPAA FVPNPYIISA APPGTDPYTA AGLAAAATLA GPAVVPPQYY GVPWGVYPAN 300
LFQQQAAAAA NNTASQQAAS QAQPGQQQVL RAGAGQRPLT PNQGQQGQQA ESLAAAAAAN 360
PTLAFGQGLA TGMPGYQVLA PTAYYDQTGA LVVGPGARTG LGAPVRLMAP TPVLISSAAA 420
QAAAAAAAGG TASSLTGSTN GLFRPIGTQP PQQQQQQPST NLQSNSFYGS SSLTNSSQSS 480
SLFSHGPGQP GSTSLGFGSG NSLGAAIGSA LSGFGSSVGS SASSSATRRE SLSTSSDLYK 540
RSSSSLAPIG QPFYNSLGFS SSPSPIGMPL PSQTPGHSLT PPPSLSSHGS SSSLHLGGLT 600
NGSGRYISAA PGAEAKYRSA SSTSSLFSSS SQLFPPSRLR YNRSDIMPSG RSRLLEDFRN 660
NRFPNLQLRD LIGHIVEFSQ DQHGSRFIQQ KLERATPAER QMVFNEILQA AYQLMTDVFG 720
NYVIQKFFEF GSLDQKLALA TRIRGHVLPL ALQMYGCRVI QKALESISSD QQSEMVKELD 780
GHVLKCVKDQ NGNHVVQKCI ECVQPQSLQF IIDAFKGQVF VLSTHPYGCR VIQRILEHCT 840
AEQTLPILEE LHQHTEQLVQ DQYGNYVIQH VLEHGRPEDK SKIVSEIRGK VLALSQHKFA 900
SNVVEKCVTH ASRAERALLI DEVCCQNDGP HSALYTMMKD QYANYVVQKM IDMAEPAQRK 960
IIMHKIRPHI TTLRKYTYGK HILAKLEKYY LKNSPDLGPI GGPPNGML 1008 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0010494; C:cytoplasmic stress granule; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:Compara.
 GO:0034063; P:stress granule assembly; IEA:Compara. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR001313; Pumilio_RNA-bd_rpt. 
Pfam
 PF00806; PUF 
SMART
 SM00025; Pumilio 
PROSITE
 PS50302; PUM
 PS50303; PUM_HD 
PRINTS