CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024308
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin repeat domain-containing protein 18B 
Protein Synonyms/Alias
  
Gene Name
 ANKRD18B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
275NQETAAMKPENLKKRubiquitination[1]
404SQQLNDLKAENARLNubiquitination[2]
594RDCLENGKEDLLEERubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 REPEAT 67 96 ANK 1.
 REPEAT 100 129 ANK 2.
 REPEAT 133 162 ANK 3.
 REPEAT 166 195 ANK 4.
 REPEAT 199 228 ANK 5.  
Keyword
 ANK repeat; Coiled coil; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1011 AA 
Protein Sequence
MRKLLSFGRR LGQALLSSMD QEYAGRGYHI RDWELRKIHR AAIKGDAAEV EHCLTRRFRD 60
LDVRDRKDRT VLHLACAHGR VQVVTLLLDR KCQINICDRL NRTPLMKAVH CQEEACAIIL 120
LKRGANPNIK DIYGNTALHY AVYNEGTSLA ERLLSHHANI EALNKEGNTP LLFAINSRRQ 180
HMVEFLLKNQ ANIHAVDNFK RTALILAVQH NLSSIVTLLL QQNIHISSQD MFGQTAEDYA 240
FCCDLRSIQQ QILEHKNKML KNHLRNDNQE TAAMKPENLK KRKKRKKLKK RKEGAKAEHN 300
LKVASEEKQE RLERSENKQP QDSQSYGKKK DEMFGNFMLK RDIAMLKEEL YAIKNDSLRK 360
EKKYIQEIKS ITEINANFEK SVRLNEEMIT KKVAQYSQQL NDLKAENARL NSKLEKEKHN 420
KERLEAEVES LHSNLATAIN EYNEILERKD LELVLWRADD VSRHETMGSN ISQLTDKNEL 480
LTEQVHKARV KFNTLKGKLR ETRDALREKT LALESVQLDL KQAQHRIKEM KQMHPNGEAK 540
ESQSIGKQNS SEERIRQREL ENLLLERQLE DARKEGDNKE IVINIHRDCL ENGKEDLLEE 600
RNKELMNEYN YLKEKLLQYE KEKAEREVIV REFQEELVDH LKKFSMSESP LEGTSHCHIN 660
LDETWTSKKK LFQVEIQPEE KHEEFRKVFE LISLLNYTAD QIRKKNRELE EEATGYKKCL 720
EMTINMLNAF ANEDFSCHGD LNTDQLKMDI LFKKLKQKFD DLMAEKEAVS SKCVNLAKDN 780
EVLHQELLSM GKVQEKCEKL EKDKKMLEEK VLNLKTHMEK DMVELGKVQE YKSELDERAM 840
QAIEKLEEIH LQKQAEYEKQ LEQLNKDNTA SLKKKELTLK DVECKFSKMK TAYEDVTTEL 900
EEYKEAFAVA LKANSSMSEK ITKSDKKIAV ISTKLFMEKE RMEYFLSTLP MRPDPELPCV 960
ENLNSIELNR KYIPKMAIRI PTSNPQTSNN CKNSLTELLL RWALAPIYFL L 1011 
Gene Ontology
  
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR021885; DUF3496. 
Pfam
 PF12796; Ank_2
 PF12001; DUF3496 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS