UniProt Accession

 TIM10_RAT; P62074; Q5BKD3; Q9WV99; Q9WVA0; Q9Y5J8 

Genbank Protein ID

 AF150091; BC091116 

Genbank Nucleotide ID

 AAD39997.1; AAH91116.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit Tim10 

Protein Synonyms/Alias

  

Gene Name

 Timm10 

Gene Synonyms/Alias

 Tim10 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
57	CLDRCVSKYLDIHER	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). 

Sequence Annotation

 MOTIF 29 54 Twin CX3C motif.
 DISULFID 29 54 By similarity.
 DISULFID 33 50 By similarity.  

Keyword

 Chaperone; Complete proteome; Disulfide bond; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Protein transport; Reference proteome; Translocation; Transport; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 90 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0042719; C:mitochondrial intermembrane space protein transporter complex; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005215; F:transporter activity; IEA:Compara.
 GO:0072321; P:chaperone-mediated protein transport; IEA:Compara.
 GO:0045039; P:protein import into mitochondrial inner membrane; IEA:Compara. 

Interpro

 IPR004217; Tim10/DDP_fam_Znf.
 IPR027247; Tim10/Tim12. 

Pfam

 PF02953; zf-Tim10_DDP 

SMART

  

PROSITE

  

PRINTS