UniProt Accession

 FRIH_RAT; P19132 

Genbank Protein ID

 M18053; M18051; M18052; U58829; M29330 

Genbank Nucleotide ID

 AAA41153.1; AAA41153.1; AAA41153.1; AAB39890.1; AAA42300.1 

Protein Name

 Ferritin heavy chain 

Protein Synonyms/Alias

 Ferritin H subunit 

Gene Name

 Fth1 

Gene Synonyms/Alias

 Fth 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
54	VALKNFAKYFLHQSH	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). 

Sequence Annotation

 DOMAIN 11 160 Ferritin-like diiron.
 METAL 28 28 Iron 1 (By similarity).
 METAL 63 63 Iron 1 (By similarity).
 METAL 63 63 Iron 2 (By similarity).
 METAL 66 66 Iron 1 (By similarity).
 METAL 108 108 Iron 2 (By similarity).
 METAL 142 142 Iron 2 (By similarity).  

Keyword

 Complete proteome; Direct protein sequencing; Iron; Iron storage; Metal-binding; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0008199; F:ferric iron binding; IEA:InterPro.
 GO:0004322; F:ferroxidase activity; IEA:EC.
 GO:0006879; P:cellular iron ion homeostasis; IEA:UniProtKB-KW.
 GO:0006955; P:immune response; ISS:UniProtKB.
 GO:0006826; P:iron ion transport; IEA:InterPro.
 GO:0048147; P:negative regulation of fibroblast proliferation; IDA:UniProtKB.
 GO:0060547; P:negative regulation of necrotic cell death; IMP:RGD. 

Interpro

 IPR001519; Ferritin.
 IPR009040; Ferritin-like_diiron.
 IPR009078; Ferritin-like_SF.
 IPR012347; Ferritin-rel.
 IPR014034; Ferritin_CS.
 IPR008331; Ferritin_DPS_dom. 

Pfam

 PF00210; Ferritin 

SMART

  

PROSITE

 PS00540; FERRITIN_1
 PS00204; FERRITIN_2
 PS50905; FERRITIN_LIKE 

PRINTS