CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018915
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative deoxyribonuclease TATDN2 
Protein Synonyms/Alias
  
Gene Name
 TATDN2 
Gene Synonyms/Alias
 KIAA0218 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
211GEAATRAKPSAAEHPubiquitination[1]
517SFQGTFTKFRKIYSSubiquitination[1]
528IYSSSFPKEFQGCISubiquitination[1]
611TPVPEQHKVFERQLQubiquitination[1]
625QLAVSLKKPLVIHCRubiquitination[1]
643EDLLEIMKKFVPPDYubiquitination[2]
644DLLEIMKKFVPPDYKubiquitination[1]
651KFVPPDYKIHRHCFTubiquitination[1]
718FLPRQVPKSLCQYAHubiquitination[1]
740VREIARVKDQPLSLTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Putative deoxyribonuclease (By similarity). 
Sequence Annotation
 METAL 499 499 Divalent metal cation 1 (By similarity).
 METAL 501 501 Divalent metal cation 1 (By similarity).
 METAL 593 593 Divalent metal cation 1 (By similarity).
 METAL 593 593 Divalent metal cation 2 (By similarity).
 METAL 630 630 Divalent metal cation 2 (By similarity).
 METAL 655 655 Divalent metal cation 2 (By similarity).
 METAL 707 707 Divalent metal cation 1 (By similarity).
 MOD_RES 420 420 Phosphoserine.  
Keyword
 Complete proteome; Hydrolase; Metal-binding; Nuclease; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 761 AA 
Protein Sequence
MASERGKVKH NWSSTSEGCP RKRSCLREPC DVAPSSRPAQ RSASRSGGPS SPKRLKAQKE 60
DDVACSRRLS WGSSRRRNNS SSSFSPHFLG PGVGGAASKG CLIRNTRGFL SSGGSPLRPA 120
NASLEEMASL EEEACSLKVD SKDSSHNSTN SEFAAEAEGQ NDTIEEPNKV QKRKRDRLRD 180
QGSTMIYLKA IQGILGKSMP KRKGEAATRA KPSAAEHPSH GEGPARSEGP AKTAEGAARS 240
VTVTAAQKEK DATPEVSMEE DKTVPERSSF YDRRVVIDPQ EKPSEEPLGD RRTVIDKCSP 300
PLEFLDDSDS HLEIQKHKDR EVVMEHPSSG SDWSDVEEIS TVRFSQEEPV SLKPSAVPEP 360
SSFTTDYVMY PPHLYSSPWC DYASYWTSSP KPSSYPSTGS SSNDAAQVGK SSRSRMSDYS 420
PNSTGSVQNT SRDMEASEEG WSQNSRSFRF SRSSEEREVK EKRTFQEEMP PRPCGGHASS 480
SLPKSHLEPS LEEGFIDTHC HLDMLYSKLS FQGTFTKFRK IYSSSFPKEF QGCISDFCDP 540
RTLTDCLWEE LLKEDLVWGA FGCHPHFARY YSESQERNLL QALRHPKAVA FGEMGLDYSY 600
KCTTPVPEQH KVFERQLQLA VSLKKPLVIH CREADEDLLE IMKKFVPPDY KIHRHCFTGS 660
YPVIEPLLKY FPNMSVGFTA VLTYSSAWEA REALRQIPLE RIIVETDAPY FLPRQVPKSL 720
CQYAHPGLAL HTVREIARVK DQPLSLTLAA LRENTSRLYS L 761 
Gene Ontology
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0016888; F:endodeoxyribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. 
Interpro
 IPR018228; DNase_TatD-rel_CS.
 IPR001130; TatD_family. 
Pfam
 PF01026; TatD_DNase 
SMART
  
PROSITE
 PS01137; TATD_1
 PS01090; TATD_2
 PS01091; TATD_3 
PRINTS