UniProt Accession

 NCF4_HUMAN; Q15080; A8K4F9; O60808; Q86U56; Q9BU98; Q9NP45 

Genbank Protein ID

 X77094; U50729; U50720; U50721; U50722; U50723; U50724; U50725; U50726; U50727; U50728; AB025220; AB025219; CR456528; BT007346; AK290924; DQ314880; AL008637; AL008637; BC002798 

Genbank Nucleotide ID

 CAA54372.1; AAB39970.1; AAB39970.1; AAB39970.1; AAB39970.1; AAB39970.1; AAB39970.1; AAB39970.1; AAB39970.1; AAB39970.1; AAB39970.1; BAA89792.1; BAA89791.1; CAG30414.1; AAP36010.1; BAF83613.1; ABC40739.1; CAQ10741.1; CAA15486.1; AAH02798.1 

Protein Name

 Neutrophil cytosol factor 4 

Protein Synonyms/Alias

 NCF-4; Neutrophil NADPH oxidase factor 4; SH3 and PX domain-containing protein 4; p40-phox; p40phox 

Gene Name

 NCF4 

Gene Synonyms/Alias

 SH3PXD4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
225	IFPLSFVKILKDFPE	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. 

Sequence Annotation

 DOMAIN 19 140 PX.
 DOMAIN 170 229 SH3.
 DOMAIN 237 329 OPR.
 MOD_RES 154 154 Phosphothreonine.
 MOD_RES 315 315 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Chronic granulomatous disease; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Phosphoprotein; Polymorphism; Reference proteome; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 339 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0043020; C:NADPH oxidase complex; IDA:UniProtKB.
 GO:0032010; C:phagolysosome; TAS:Reactome.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0046983; F:protein dimerization activity; TAS:UniProtKB.
 GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0006955; P:immune response; TAS:UniProtKB.
 GO:0051701; P:interaction with host; TAS:Reactome.
 GO:0055114; P:oxidation-reduction process; TAS:UniProtKB.
 GO:0090382; P:phagosome maturation; TAS:Reactome. 

Interpro

 IPR000919; NCF_P40.
 IPR000270; OPR_PB1.
 IPR001683; Phox.
 IPR001452; SH3_domain. 

Pfam

 PF00564; PB1
 PF00787; PX
 PF00018; SH3_1 

SMART

 SM00666; PB1
 SM00312; PX
 SM00326; SH3 

PROSITE

 PS50195; PX
 PS50002; SH3 

PRINTS

 PR00497; P40PHOX.