CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041047
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable ATP-dependent RNA helicase DDX46 
Protein Synonyms/Alias
  
Gene Name
 Ddx46 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
772KSSGFSGKGFKFDETacetylation[1, 2]
775GFSGKGFKFDETEQAacetylation[2]
844PTAGNAEKLEIAKRLacetylation[1]
891LAPTVSAKTIAEQLAacetylation[1]
891LAPTVSAKTIAEQLAubiquitination[3]
900IAEQLAEKINAKLNYacetylation[2]
900IAEQLAEKINAKLNYubiquitination[3]
904LAEKINAKLNYVPLEacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1028 AA 
Protein Sequence
MGRESRHYRK RSASRGRSGS RSRSRSPSDK RSKRGDDRRS RSRDRDRRRE RSRSRDKRRS 60
RSRDRKRLRR SRSRERDRSR ERRRSRSRDR RRSRSRSRGR RSRSSSPGSK TKKTENRSRS 120
KEKAEGGDSS KEKKKDKDDK EDEKEKDAGN FDQNKLEEEM RKRKERVEKW REEQRKKAME 180
NIGELKKEIE EMKQGKKWSL EDDDDDEDDP AEAEKEGTEM EDEELDPLDA YMEEVKEEVK 240
KFNMRSVKGG AGNEKKSGPT VTKVVTVVTT KKAVVDADKK KGELMENDQD AMEYSSEEEE 300
VDLQTALTGY QTKQRKLLEP VDHGKIEYEP FRKNFYVEVP ELAKMSQEEV NVFRLEMEGI 360
TVKGKGCPKP IKSWVQCGIS MKILNSLKKH GYEKPTPIQT QAIPAIMSGR DLIGIAKTGS 420
GKTIAFLLPM FRHIMDQRSL EEGEGPIAVI MTPTRELALQ ITKECKKFSK TLGLRVVCVY 480
GGTGISEQIA ELKRGAEIIV CTPGRMIDML AANSGKSRVF YYLFSLLFVL DMIFVEADVM 540
RIVDNVRPDR QTVMFSATFP RAMEALARRI LSKPIEVQVG GRSVVCSDVE QQVIVIEEEK 600
KFLKLLELLG HYQESGSVII FVDKQEHADG LLKDLMRASY PCMSLHGGID QYDRDSIIND 660
FKNGTCKLLV ATSVAARGLD VKHLILVVNY SCPNHYEDYV HRAGRTGRAG NKGYAYTFIT 720
EDQARYAGDI IKALELSGTA VPPDLEKLWS DFKDQQKAEG KIIKKSSGFS GKGFKFDETE 780
QALANERKKL QKAALGLQDS DDEDAAVDID EQIESMFNSK KRVKDMAAPG TSSVPAPTAG 840
NAEKLEIAKR LALRINAQKN LGIESQVDVM QQATNAILRG GTILAPTVSA KTIAEQLAEK 900
INAKLNYVPL EKQEEERQEG GQSESFKRYE EELEINDFPQ TARWKVTSKE ALQRISEYSE 960
AAITIRGTYF PPGKEPKEGE RKIYLAIESA NELAVQKAKA EITRLIKEEL IRLQNSYQPT 1020
NKGRYKVL 1028 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR014014; RNA_helicase_DEAD_Q_motif. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 
PRINTS