CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011568
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial distribution and morphology protein 38 
Protein Synonyms/Alias
  
Gene Name
 MDM38 
Gene Synonyms/Alias
 YOL027C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
321ACVSRGMKAYGVSKEacetylation[1]
418KLDVSESKSSAAETEubiquitination[2]
428AAETEAEKQVAEKKIubiquitination[2]
488TEEISQEKENAEPTDacetylation[1]
488TEEISQEKENAEPTDubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation. 
Sequence Annotation
 DOMAIN 80 354 LETM1.  
Keyword
 3D-structure; Coiled coil; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 573 AA 
Protein Sequence
MLNFASRASC VTRRQASLYF VKNQGPRLIA STIPSCHWPL RAQGVQPNYP LSLRFYSTDK 60
SKSVTKPVAP TSTDAPAKPK ETLMVKVKHA LKHYANGTKL LGYEIKVSTK LLIKFAQGYE 120
LSRRERNQLR RTMGDVFRLI PFSAFLIIPF AELFLPFALK LFPNLLPSTY ESGKDKQAKR 180
NKLIEIRKKT SEFLHETLEE SNLITYNTIE NAEKKQKFLN FFRKLYSAKE GKIMTFQHDE 240
ISAIAQMFKN DSVLDNLSRP QLAAMSKFMS LRPFGNDNML RYQIRSKLKD IMNDDKTIDY 300
EGVESLSQEE LYQACVSRGM KAYGVSKEDL VDNLKVWLEL RLRQKIPSVL MVLSSTFTFG 360
GLPKENYSKA FSPLAEKKET KSKYDDLLDL YYDGILQVLS SIPDPVYNVA KLDVSESKSS 420
AAETEAEKQV AEKKIKTEEK PEETAIPKEE ATAKESVIAT TASAVTPKLV VVNEKAETAK 480
TEEISQEKEN AEPTDSAEAT EAEEKKTSDD NEFKLNVLKE QEELIKKEEE EAKQRASREH 540
VPDDINLDEE EEAKSVPPIP ADQAAKTFVI KKD 573 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
 GO:0043022; F:ribosome binding; IDA:SGD.
 GO:0030007; P:cellular potassium ion homeostasis; IMP:SGD.
 GO:0097033; P:mitochondrial respiratory chain complex III biogenesis; IMP:SGD.
 GO:0097034; P:mitochondrial respiratory chain complex IV biogenesis; IMP:SGD.
 GO:0070131; P:positive regulation of mitochondrial translation; IGI:SGD.
 GO:0006813; P:potassium ion transport; IMP:SGD.
 GO:0051204; P:protein insertion into mitochondrial membrane; IMP:SGD.
 GO:0015992; P:proton transport; IGI:SGD. 
Interpro
 IPR011685; LETM1. 
Pfam
 PF07766; LETM1 
SMART
  
PROSITE
  
PRINTS