CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001931
UniProt Accession
Genbank Protein ID
  
Genbank Nucleotide ID
  
Protein Name
 Hemoglobin subunit alpha 
Protein Synonyms/Alias
 Alpha-globin; Hemoglobin alpha chain 
Gene Name
 HBA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
8MVLSAADKNNVKTTWacetylation[1]
12AADKNNVKTTWDKIGacetylation[1]
17NVKTTWDKIGGHAAEacetylation[1]
41FTSFPTTKTYFHHIDacetylation[1]
57SPGSGDIKAHGKKVAacetylation[1]
61GDIKAHGKKVADALTacetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019
Functional Description
 Involved in oxygen transport from the lung to the various peripheral tissues. 
Sequence Annotation
 METAL 59 59 Iron (heme distal ligand).
 METAL 88 88 Iron (heme proximal ligand).
 MOD_RES 17 17 N6-acetyllysine (By similarity).  
Keyword
 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 142 AA 
Protein Sequence
MVLSAADKNN VKTTWDKIGG HAAEYVAEGL TRMFTSFPTT KTYFHHIDVS PGSGDIKAHG 60
KKVADALTTA VGHLDDLPTA LSTLSDVHAH KLRVDPVNFK FLNHCLLVTL AAHLGADFTP 120
SIHASLDKFF ASVSTVLTSK YR 142 
Gene Ontology
 GO:0005833; C:hemoglobin complex; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0019825; F:oxygen binding; IEA:InterPro.
 GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW. 
Interpro
 IPR000971; Globin.
 IPR009050; Globin-like.
 IPR012292; Globin_dom.
 IPR002338; Haemoglobin_a.
 IPR018331; Haemoglobin_alpha_chain. 
Pfam
 PF00042; Globin 
SMART
  
PROSITE
 PS01033; GLOBIN 
PRINTS
 PR00612; ALPHAHAEM.