UniProt Accession

 DHSB_HUMAN; P21912; B2R545; Q9NQ12 

Genbank Protein ID

 U17248; U17886; U17296; U17880; U17881; U17882; U17883; U17884; U17885; AK312056; AL049569; CH471134; BC007840; D10245; M32246 

Genbank Nucleotide ID

 AAA81167.1; AAA80581.1; AAA80581.1; AAA80581.1; AAA80581.1; AAA80581.1; AAA80581.1; AAA80581.1; AAA80581.1; BAG34992.1; CAB96822.1; EAW94828.1; AAH07840.1; BAA01089.1; AAA35708.1 

Protein Name

 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial 

Protein Synonyms/Alias

 Iron-sulfur subunit of complex II; Ip 

Gene Name

 SDHB 

Gene Synonyms/Alias

 SDH; SDH1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
80	LDALIKIKNEVDSTL	ubiquitination	[1]
123	RIDTNLNKVSKIYPL	ubiquitination	[1, 2, 3]
151	SNFYAQYKSIEPYLK	ubiquitination	[1]
167	KDESQEGKQQYLQSI	ubiquitination	[1]
233	FTEERLAKLQDPFSL	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). 

Sequence Annotation

 DOMAIN 40 133 2Fe-2S ferredoxin-type.
 DOMAIN 176 206 4Fe-4S ferredoxin-type.
 METAL 93 93 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 98 98 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 101 101 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 113 113 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 186 186 Iron-sulfur 2 (4Fe-4S) (By similarity).
 METAL 189 189 Iron-sulfur 2 (4Fe-4S) (By similarity).
 METAL 192 192 Iron-sulfur 2 (4Fe-4S) (By similarity).
 METAL 196 196 Iron-sulfur 3 (3Fe-4S) (By similarity).
 METAL 243 243 Iron-sulfur 3 (3Fe-4S) (By similarity).
 METAL 249 249 Iron-sulfur 3 (3Fe-4S) (By similarity).
 METAL 253 253 Iron-sulfur 2 (4Fe-4S) (By similarity).
 BINDING 201 201 Ubiquinone; shared with DHSD (By  

Keyword

 2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Disease mutation; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide; Transport; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 280 AA 

Protein Sequence

Gene Ontology

 GO:0005749; C:mitochondrial respiratory chain complex II; ISS:UniProtKB.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; ISS:UniProtKB.
 GO:0051538; F:3 iron, 4 sulfur cluster binding; ISS:UniProtKB.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; ISS:UniProtKB.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:EC.
 GO:0048039; F:ubiquinone binding; ISS:UniProtKB.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0006105; P:succinate metabolic process; IEA:Compara.
 GO:0006099; P:tricarboxylic acid cycle; TAS:Reactome. 

Interpro

 IPR001041; 2Fe-2S_ferredoxin-type.
 IPR006058; 2Fe2S_fd_BS.
 IPR017896; 4Fe4S_Fe-S-bd.
 IPR017900; 4Fe4S_Fe_S_CS.
 IPR012675; Beta-grasp_dom.
 IPR012285; Fum_reductase_C.
 IPR009051; Helical_ferredxn.
 IPR004489; Succ_DH/fum_Rdtase_Fe-S.
 IPR025192; Succ_DH/fum_Rdtase_N. 

Pfam

 PF13085; Fer2_3 

SMART

  

PROSITE

 PS00197; 2FE2S_FER_1
 PS51085; 2FE2S_FER_2
 PS00198; 4FE4S_FER_1
 PS51379; 4FE4S_FER_2 

PRINTS