CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043017
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ceramide synthase 2 
Protein Synonyms/Alias
  
Gene Name
 CERS2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
93HFYLTSGKQPKQVEVubiquitination[1, 2, 3, 4]
96LTSGKQPKQVEVELLubiquitination[3]
131QDRPSLLKKFREASWubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Homeobox; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 223 AA 
Protein Sequence
MLQTLYDYFW WERLWLPVNL TWADLEDRDG RVYAKASDLY ITLPLALLFL IVRYFFELYV 60
ATPLAALLNI KEKTRLRAPP NATLEHFYLT SGKQPKQVEV ELLSRQSGLS GRQVERWFRR 120
RRNQDRPSLL KKFREASWRF TFYLIAFIAG MAVIVDKPWF YDMKKVWEGY PIQSTIPSQY 180
WYYMIELSFY WSLLFSIASD VKRKDFKEQI IHHVATIILI SFS 223 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0050291; F:sphingosine N-acyltransferase activity; IEA:Compara.
 GO:0046513; P:ceramide biosynthetic process; IEA:Compara. 
Interpro
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR006634; TLC-dom. 
Pfam
 PF00046; Homeobox
 PF03798; TRAM_LAG1_CLN8 
SMART
 SM00389; HOX 
PROSITE
 PS50071; HOMEOBOX_2
 PS50922; TLC 
PRINTS