CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039031
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cytoplasmic dynein 1 heavy chain 1 
Protein Synonyms/Alias
  
Gene Name
 Dync1h1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
233KVTDFGDKVEDPTFLacetylation[1]
368LRKIRNTKYPIQRALacetylation[1]
391DLSSQLLKVLGTRKLacetylation[1]
610TQLIQRVKDDIESLHacetylation[1]
619DIESLHDKFKVQYPQacetylation[1]
649SGSIIWAKQIDRQLTubiquitination[2]
689DGDSFRMKLNTQEIFacetylation[1]
733SGNVLKLKVNFLPEIacetylation[1]
751SKEVRNLKWLGFRVPacetylation[1]
953PGGEPKIKNVVHELRacetylation[1]
1108PVVIDYGKVQSKVNLacetylation[1]
1116VQSKVNLKYDSWHKEacetylation[1]
1122LKYDSWHKEVLSKFGacetylation[1]
1368DGLLNQLKNFPARLRacetylation[1]
1388EFVQRLLKGYMKINMacetylation[1]
1577TEFLALMKKVSKSPLacetylation[1]
1646GNSKNVAKLQKHFKKacetylation[1]
2439KALEHAFKLEHIMDLacetylation[1]
3206NVGLRKIKETVDQVEacetylation[1]
3477NRSTALLKSLSAEREacetylation[1]
3754LQALNEVKGRILDDDubiquitination[2]
3771ITTLENLKREAAEVTacetylation[1]
4234RQNISPDKIPWSALKacetylation[1]
4280RSFDSEFKLACKVDGacetylation[1]
4396PQTLSPLKRTVENIKacetylation[1]
4403KRTVENIKDPLFRFFacetylation[1]
4454TLINELVKGILPRSWacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4643 AA 
Protein Sequence
MSETGGGEDG SAGLEVSAVQ NVADVSVLQK HLRKLVPLLL EDGGDAPAAL EAALEEKSAL 60
EQMRKFLSDP QVHTVLVERS TLKEDVGDEG EEEKEFISYN INIDIHYGVK SNSLAFIKRA 120
PVIDADKPVS SQLRVLTLSE DSPYETLHSF ISNAVAPFFK SYIRESGKAD RDGDKMAPSV 180
EKKIAELEMG LLHLQQNIEI PEISLPIHPI ITNVAKQCYE RGEKPKVTDF GDKVEDPTFL 240
NQLQSGVNRW IREIQKVRAL DVQAALGSGQ SRIKGFYNTI HGFNCTPKKT KTECTRDIVC 300
LKYSRYFSIE VNFVVQTGLK QALETVNDYN PLMKDFPLND LLSATELDKI RQALVAIFTH 360
LRKIRNTKYP IQRALRLVEA ISRDLSSQLL KVLGTRKLMH VAYEEFEKVM VACFEVFQTW 420
DDEYEKLQVL LRDIVKRKRE ENLKMVWRIN PAHRKLQARL DQMRKFRRQH EQLRAVIVRV 480
LRPQVTAVAQ QNQGEAPEPQ DMKVAEVLFD AADANAIEEV NLAYENVKEV DGLDVSKEGT 540
EAWEAAMKRY DERIDRVETR ITARLRDQLG TAKNANEMFR IFSRFNALFV RPHIRGAIRE 600
YQTQLIQRVK DDIESLHDKF KVQYPQSQAC KMSHVRDLPP VSGSIIWAKQ IDRQLTAYMK 660
RVEDVLGKGW ENHVEGQKLK QDGDSFRMKL NTQEIFDDWA RKVQQRNLGV SGRIFTIESA 720
RVRGRSGNVL KLKVNFLPEI ITLSKEVRNL KWLGFRVPLA IVNKAHQANQ LYPFAISLIE 780
SVRTYERTCE KVEERNTISL LVAGLKKEVQ ALIAEGIALV WESYKLDPYV QRLAETVFNF 840
QEKVDDLLII EEKIDLEVRS LETCMYDHKT FSEILNRVQK AVDDLNLHSY SNLPIWVNKL 900
DMEIERILGV RLQAGLRAWT QVLLGQAEDK AEVDMDTDAP QVSHKPGGEP KIKNVVHELR 960
ITNQVIYLNP PIEECRYKLY QEMFAWKMIV LSLPRIQSQR YQVGVHYELT EEEKFYRNAL 1020
TRMPDGPVAL EESYSAVMGI VTEVEQYVKV WLQYQCLWDM QAENIYNRLG EDLSKWQALL 1080
VQIRRARGTF DNAETKKEFG PVVIDYGKVQ SKVNLKYDSW HKEVLSKFGQ MLGSNMTEFH 1140
SQISKSRQEL EQHSVDTAST SDAVTFITYV QSLKRKIKQF EKQVELYRNG QRLLEKQRFQ 1200
FPPSWLYIDN IEGEWGAFND IMRRKDSAIQ QQVANLQMKI VQEDRAVESR TTDLLTDWEK 1260
TKPVTGNLRP EEALQALTIY EGKFGRLKDD REKCAKAKEA LELTDTGLLS GSEERVQVAL 1320
EELQDLKGVW SELSKVWEQI DQMKEQPWVS VQPRKLRQNL DGLLNQLKNF PARLRQYASY 1380
EFVQRLLKGY MKINMLVIEL KSEALKDRHW KQLMKRLHVN WVVSELTLGQ IWDVDLQKNE 1440
AIVKDVLLVA QGEMALEEFL KQIREVWNTY ELDLVNYQNK CRLIRGWDDL FNKVKEHINS 1500
VSAMKLSPYY KVFEEDALSW EDKLNRIMAL FDVWIDVQRR WVYLEGIFTG SADIKHLLPV 1560
ETQRFQSIST EFLALMKKVS KSPLVMDVLN IQGVQRSLER LADLLGKIQK ALGEYLERER 1620
SSFPRFYFVG DEDLLEIIGN SKNVAKLQKH FKKMFAGVSS IILNEDSSVV LGISSREGEE 1680
VMFKTPVSIT EHPKINEWLT LVEKEMRVTL AKLLAESVTE VEIFGKATSI DPNTYITWID 1740
KYQAQLVVLS AQIAWSENVE NALSNVGGGG DVGPLQSVLS NVEVTLNVLA DSVLMEQPPL 1800
RRRKLEHLIT ELVHQRDVTR SLIKSKIDNA KSFEWLSQMR FYFDPKQTDV LQQLSIQMAN 1860
AKFNYGFEYL GVQDKLVQTP LTDRCYLTMT QALEARLGGS PFGPAGTGKT ESVKALGHQL 1920
GRFVLVFNCD ETFDFQAMGR IFVGLCQVGA WGCFDEFNRL EERMLSAVSQ QVQCIQEALR 1980
EHSNPNYDKT SAPITCELLN KQVKVSPDMA IFITMNPGYA GRSNLPDNLK KLFRSLAMTK 2040
PDRQLIAQVM LYSQGFRTAE VLANKIVPFF KLCDEQLSSQ SHYDFGLRAL KSVLVSAGNV 2100
KRERIQKIKR EKEERGEAVD EGEIAENLPE QEILIQSVCE TMVPKLVAED IPLLFSLLSD 2160
VFPGVQYHRG EMTALREELK KVCQEMYLTY GDGEEVGGMW VEKVLQLYQI TQINHGLMMV 2220
GPSGSGKSMA WRVLLKALER LEGVEGVAHI IDPKAISKDH LYGTLDPNTR EWTDGLFTHV 2280
LRKIIDNVRG ELQKRQWIVF DGDVDPEWVE NLNSVLDDNK LLTLPNGERL SLPPNVRIMF 2340
EVQDLKYATL ATVSRCGMVW FSEDVLSTDM IFNNFLARLR SIPLDEGEDE AQRRRKGKED 2400
EGEEAASPML QIQRDAATIM QPYFTSNGLV TKALEHAFKL EHIMDLTRLR CLGSLFSMLH 2460
QACRNVAQYN ANHPDFPMQI EQLERYIQRY LVYAILWSLS GDSRLKMRAE LGEYIRRITT 2520
VPLPTAPNIP IIDYEVSISG EWSPWQAKVP QIEVETHKVA APDVVVPTLD TVRHEALLYT 2580
WLAEHKPLVL CGPPGSGKTM TLFSALRALP DMEVVGLNFS SATTPELLLK TFDHYCEYRR 2640
TPNGVVLAPV QLGKWLVLFC DEINLPDMDK YGTQRVISFI RQMVEHGGFY RTSDQTWVKL 2700
ERIQFVGACN PPTDPGRKPL SHRFLRHVPV VYVDYPGPAS LTQIYGTFNR AMLRLIPSLR 2760
TYAEPLTAAM VEFYTMSQER FTQDTQPHYI YSPREMTRWV RGIFEALRPL ETLPVEGLIR 2820
IWAHEALRLF QDRLVEDEER RWTDENIDMV ALKHFPNIDK EKAMSRPILY SNWLSKDYIP 2880
VDQEELRDYV KARLKVFYEE ELDVPLVLFN EVLDHVLRID RIFRQPQGHL LLIGVSGAGK 2940
TTLSRFVAWM NGLSVYQIKV HRKYTGEDFD EDLRTVLRRS GCKNEKIAFI MDESNVLDSG 3000
FLERMNTLLA NGEVPGLFEG DEYATLMTQC KEGAQKEGLM LDSHEELYKW FTSQVIRNLH 3060
VVFTMNPSSE GLKDRAATSP ALFNRCVLNW FGDWSTEALY QVGKEFTSKM DLEKPNYIVP 3120
DYMPVVYDKL PQPPTHREAI VNSCVFVHQT LHQANARLAK RGGRTMAITP RHYLDFINHY 3180
ANLFHEKRSE LEEQQMHLNV GLRKIKETVD QVEELRRDLR IKSQELEVKN AAANDKLKKM 3240
VKDQQEAEKK KVMSQEIQEQ LHKQQEVIAD KQMSVKEDLD KVEPAVIEAQ NAVKSIKKQH 3300
LVEVRSMANP PAAVKLALES ICLLLGESTT DWKQIRSIIM RENFIPTIVN FSAEEISDAI 3360
REKMKKNYMS NPSYNYEIVN RASLACGPMV KWAIAQLNYA DMLKRVEPLR NELQKLEDDA 3420
KDNQQKANEV EQMIRDLEAS IARYKEEYAV LISEAQAIKA DLAAVEAKVN RSTALLKSLS 3480
AERERWEKTS ETFKNQMSTI AGDCLLSAAF IAYAGYFDQQ MRQNLFTTWS HHLQQANIQF 3540
RTDIARTEYL SNADDALRWQ ASSLPADDLC TENAIMLKRF NRYPLIIDPS GQATEFIMNE 3600
YKDRKITRTS FLDDAFRKNL ESALRFGNPL LVQDVESYDP VLNPVLNREV RRTGGRVLIT 3660
LGDQDIDLSP SFVIFLSTRD PTVEFPPDLC SRVTFVNFTV TRSSLQSQCL NEVLKAERPD 3720
VDEKRSDLLK LQGEFQLRLR QLEKSLLQAL NEVKGRILDD DTIITTLENL KREAAEVTRK 3780
VEETDIVMQE VETVSQQYLP LSTACSSIYF TMESLKQVHF LYQYSLQFFL DIYHNVLYEN 3840
PNLKGATDHT QRLSVITKDL FQVAFNRVAR GMLHQDHITF AMLLARIKLK GTMGEPTYDA 3900
EFQHFLRGKE IVLSAGSTPK VQGLTVEQAE AVARLSCLPA FKDLIAKVQA DEQFGIWLES 3960
SSPEQTVPYL WTEETPATPI GQAIHRLLLI QAFRPDRLLA MAHMFVSTNL GESFMSIMEQ 4020
PLDLTHIVGT EVKPNTPVLM CSVPGYDASG HVEDLAAEQN TQITSIAIGS AEGFNQADKA 4080
INTAVKSGRW VMLKNVHLAP GWLMQLEKKL HSLQPHACFR LFLTMEINPK VPVNLLRAGR 4140
IFVFEPPPGV KANMLRTFSS IPVSRMCKSP NERARLYFLL AWFHAVIQER LRYAPLGWSK 4200
KYEFGESDLR SACDTVDTWL DDTAKGRQNI SPDKIPWSAL KTLMAQSIYG GRVDNEFDQR 4260
LLNTFLERLF TTRSFDSEFK LACKVDGHKD IQMPDGIRRE EFVQWVELLP DAQTPSWLGL 4320
PNNAERVLLT TQGVDMISKM LKMQMLEDED DLAYAETEKK TRTDSTSDGR PAWMRTLHTT 4380
ASNWLHLIPQ TLSPLKRTVE NIKDPLFRFF EREVKMGAKL LQDVRQDLAD VVQVCEGKKK 4440
QTNYLRTLIN ELVKGILPRS WSHYTVPAGM TVIQWVSDFS ERIKQLQNIS QAAAAGGAKE 4500
LKNIHVCLGG LFVPEAYITA TRQYVAQANS WSLEELCLEV NVTASQSTTL DACSFGVTGL 4560
KLQGATCSNN KLSLSNAIST VLPLTQLRWG KQTSAEKKAS VVTLPVYLNF TRADLIFTVD 4620
FEIATKEDPR SFYERGVAVL CTE 4643 
Gene Ontology
 GO:0030286; C:dynein complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR026983; DHC_fam.
 IPR025290; DUF4151.
 IPR024743; Dynein_HC_stalk.
 IPR024317; Dynein_heavy_chain_D4_dom.
 IPR004273; Dynein_heavy_dom.
 IPR013594; Dynein_heavy_dom-1.
 IPR013602; Dynein_heavy_dom-2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF07728; AAA_5
 PF12780; AAA_8
 PF08385; DHC_N1
 PF08393; DHC_N2
 PF13666; DUF4151
 PF03028; Dynein_heavy
 PF12777; MT 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS