CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015848
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myb-binding protein 1A 
Protein Synonyms/Alias
 Myb-binding protein of 160 kDa 
Gene Name
 Mybbp1a 
Gene Synonyms/Alias
 P160 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
9AEMKSPTKAEPATPAacetylation[1]
9AEMKSPTKAEPATPAsuccinylation[1]
54TRLRATEKLLEYLRTacetylation[2]
156KDKEALMKSVQLLKIacetylation[1, 2, 3]
162MKSVQLLKILSQHPNacetylation[1, 2]
1097LRTVNHEKLSVDLTAacetylation[3]
1156KSEKKNAKDIPSDTQacetylation[1]
1297HQEALSTKEVIRKSPacetylation[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). 
Sequence Annotation
 REGION 1 580 Interaction with MYB.
 REGION 1152 1344 Required for nuclear and nucleolar
 MOTIF 238 256 Nuclear export signal 1.
 MOTIF 261 279 Nuclear export signal 2.
 MOD_RES 6 6 Phosphoserine.
 MOD_RES 69 69 N6-acetyllysine (By similarity).
 MOD_RES 156 156 N6-acetyllysine (By similarity).
 MOD_RES 722 722 Phosphoserine.
 MOD_RES 1160 1160 Phosphoserine (By similarity).
 MOD_RES 1164 1164 Phosphoserine.
 MOD_RES 1187 1187 Phosphoserine (By similarity).
 MOD_RES 1191 1191 Phosphothreonine (By similarity).
 MOD_RES 1198 1198 Phosphoserine.
 MOD_RES 1219 1219 Phosphoserine (By similarity).
 MOD_RES 1244 1244 Phosphoserine (By similarity).
 MOD_RES 1253 1253 Phosphoserine.
 MOD_RES 1277 1277 Phosphothreonine.
 MOD_RES 1280 1280 Phosphoserine.
 MOD_RES 1318 1318 Phosphoserine (By similarity).
 MOD_RES 1323 1323 Phosphoserine (By similarity).
 MOD_RES 1325 1325 Phosphoserine (By similarity).
 MOD_RES 1329 1329 Phosphoserine (By similarity).  
Keyword
 Acetylation; Activator; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1344 AA 
Protein Sequence
MAEMKSPTKA EPATPAEAAQ SDRHSLLEHS REFLDFFWDI AKPDQETRLR ATEKLLEYLR 60
TRPNDSEMKY ALKRLITGLG VGREAARPCY SLALAQLLQS FEDIPLCDIL DQIQEKYSLQ 120
AMNKAMMRPS LFANLFGVLA LFQSGRLVKD KEALMKSVQL LKILSQHPNH LQGQPIKALV 180
DILSEVPESM FQEILPKVLK GNMKVILRSP KYLELFLLAK QRVPTKLESL MGSVDLFSED 240
NIPSLVNILK VAANSVKKEH KLPNVALDLL RLALKESRFE LFWKKVLEEG LLKNPSWTSS 300
YMCFRLLGAS LPLLSEEQLQ LVMRGDLIRH FGENMVISKP QNLFKIIPEI STYVGTFLEG 360
CQDDPKRQLT MMVAFTTITN QGLPVMPTFW RVTRFLNAEA LQSYVAWLRD MFLQPDLNSL 420
VDFSTANQKR AQDASLNVPE RAVFRLRKWI IHRLVSLVDH LHLEKDEAVV EQIARFCLFH 480
AFFKTKKATP QIPETKQHFS FPLDDRNRGV FVSAFFSLLQ TLSVKFRQTP DLAENGKPWT 540
YRLVQLADML LNHNRNVTSV TSLTTQQRQA WDQMMSTLKE LEARSSETRA IAFQHLLLLV 600
GLHIFKSPAE SCDVLGDIQT CIKKSMEQNP RRSRSRAKAS QEPVWVEVMV EILLSLLAQP 660
SNLMRQVVRS VFGHICPHLT PRCLQLILAV LSPVTNEDED DNVVVTDDAD EKQLQHGEDE 720
DSDNEDNKNS ESDMDSEDGE ESEEEDRDKD VDPGFRQQLM EVLKAGNALG GVDNEEEEEL 780
GDEAMMALDQ NLASLFKEQK MRIQARNEEK NKLQKEKKLR RDFQIRALDL IEVLVTKQPE 840
HPLILELLEP LLNVIQHSMR SKGSTKQEQD LLHKTARIFM HHLCRARRYC HEVGPCAEAL 900
HAQVERLVQQ AGSQADASVA LYYFNASLYL LRVLKGNTNK RHQDGHKLHG ADTEDSEDQA 960
ANCLDLDFVT RVYSASLESL LTKRNSSLTV PMFLSLFSRY PVICKNLLPV LAQHVAGPSR 1020
PRHQAQACLM LQKTLSAREL RVCFEDPEWE QLITQLLGKA TQTLQTLGEA QSKGEHQKEL 1080
SILELLNTLL RTVNHEKLSV DLTAPLGVLQ SKQQKLQQSL QQGNHSSGSN RLYDLYWQAM 1140
RMLGVQRPKS EKKNAKDIPS DTQSPVSTKR KKKGFLPETK KRKKLKSEGT TPEKNAASQQ 1200
DAVTEGAMPA ATGKDQPPST GKKKRKRVKA STPSQVNGIT GAKSPAPSNP TLSPSTPAKT 1260
PKLQKKKEKL SQVNGATPVS PIEPESKKHH QEALSTKEVI RKSPHPQSAL PKKRARLSLV 1320
SRSPSLLQSG VKKRRVASRR VQTP 1344 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0042564; C:NLS-dependent protein nuclear import complex; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0008134; F:transcription factor binding; TAS:UniProtKB.
 GO:0008270; F:zinc ion binding; TAS:UniProtKB.
 GO:0042149; P:cellular response to glucose starvation; IEA:Compara.
 GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0006913; P:nucleocytoplasmic transport; IDA:UniProtKB.
 GO:0071158; P:positive regulation of cell cycle arrest; IEA:Compara.
 GO:0022904; P:respiratory electron transport chain; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR016024; ARM-type_fold.
 IPR007015; DNA_pol_V. 
Pfam
 PF04931; DNA_pol_phi 
SMART
  
PROSITE
  
PRINTS