CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022671
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DnaJ homolog subfamily B member 1 
Protein Synonyms/Alias
 Heat shock 40 kDa protein 1; HSP40; Heat shock protein 40 
Gene Name
 Dnajb1 
Gene Synonyms/Alias
 Hsp40; Hspf1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
3*****MGKDYYQTLGacetylation[1]
35ALRYHPDKNKEPGAEubiquitination[2]
44KEPGAEEKFKEIAEAubiquitination[2]
46PGAEEKFKEIAEAYDubiquitination[2]
195KRLNPDGKSIRNEDKubiquitination[2]
286RTIPVVFKDVIRPGMubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP (By similarity). 
Sequence Annotation
 DOMAIN 2 70 J.  
Keyword
 Chaperone; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 340 AA 
Protein Sequence
MGKDYYQTLG LARGASDDEI KRAYRRQALR YHPDKNKEPG AEEKFKEIAE AYDVLSDPRK 60
REIFDRYGEE GLKGGSPSGG SSGGANGTSF SYTFHGDPHA MFAEFFGGRN PFDTFFGQRN 120
GEEGMDIDDT FSSFPMGMGG FTNMNFGRSR PSQEPTRKKQ DPPVTHDLRV SLEEIYSGCT 180
KKMKISHKRL NPDGKSIRNE DKILTIEVKR GWKEGTKITF PKEGDQTSNN IPADIVFVLK 240
DKPHNIFKRD GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE 300
GLPLPKTPEK RGDLVIEFEV IFPERIPVSS RTILEQVLPI 340 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0070389; P:chaperone cofactor-dependent protein refolding; IEA:Compara.
 GO:0051085; P:chaperone mediated protein folding requiring cofactor; IGI:MGI.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR002939; DnaJ_C.
 IPR001623; DnaJ_domain.
 IPR018253; DnaJ_domain_CS.
 IPR008971; HSP40/DnaJ_pept-bd. 
Pfam
 PF00226; DnaJ
 PF01556; DnaJ_C 
SMART
 SM00271; DnaJ 
PROSITE
 PS00636; DNAJ_1
 PS50076; DNAJ_2 
PRINTS
 PR00625; JDOMAIN.