CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015686
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coiled-coil domain-containing protein 25 
Protein Synonyms/Alias
  
Gene Name
 Ccdc25 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
23TIYMGKDKYENEDLIacetylation[1, 2, 3]
84ANSIQGCKMNNVNVVubiquitination[4]
148FPDLAAEKEGRDREEubiquitination[4]
167KAQIQEMKRKEKEEMubiquitination[4]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
 MOD_RES 23 23 N6-acetyllysine (By similarity).
 MOD_RES 187 187 Phosphoserine.
 MOD_RES 204 204 Phosphoserine.  
Keyword
 Acetylation; Coiled coil; Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 208 AA 
Protein Sequence
MVFYFTSSSV NSSTYTIYMG KDKYENEDLI KYGWPEDIWF HVDKLSSAHV YLRLQKGEKI 60
EDIPKEVLMD CAHLVKANSI QGCKMNNVNV VYTPWSNLKK TADMDVGQIG FHRQKDVKIV 120
TVEKKVNEIL NRLEKTKLEK FPDLAAEKEG RDREERNEKK AQIQEMKRKE KEEMKKKREM 180
DELRSYSSLM KVENMSSNQD GNDSDEFM 208 
Gene Ontology
  
Interpro
 IPR008532; DUF814. 
Pfam
 PF05670; DUF814 
SMART
  
PROSITE
  
PRINTS