UniProt Accession

 TIP_HUMAN; Q8TB96; Q96SR4; Q9BRE2; Q9H2V9 

Genbank Protein ID

 AF503339; AF212247; AK027596; BC006321; BC024162 

Genbank Nucleotide ID

 AAN31655.1; AAG41782.1; BAB55220.1; AAH06321.2; AAH24162.1 

Protein Name

 T-cell immunomodulatory protein 

Protein Synonyms/Alias

 Protein TIP; Integrin-alpha FG-GAP repeat-containing protein 1 

Gene Name

 ITFG1 

Gene Synonyms/Alias

 TIP; CDA08 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
86	DQNAPYFKPKVKVSF	ubiquitination	[1, 2]
298	YLVRSGMKQWVPVLQ	ubiquitination	[2]
526	IPRPSGEKSIRKQEW	ubiquitination	[2]
530	SGEKSIRKQEWTAII	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity). 

Sequence Annotation

 REPEAT 258 293 FG-GAP; atypical.
 CARBOHYD 36 36 N-linked (GlcNAc...) (Potential).
 CARBOHYD 95 95 N-linked (GlcNAc...) (Potential).
 CARBOHYD 139 139 N-linked (GlcNAc...) (Potential).
 CARBOHYD 146 146 N-linked (GlcNAc...) (Potential).
 CARBOHYD 151 151 N-linked (GlcNAc...) (Potential).
 CARBOHYD 176 176 N-linked (GlcNAc...) (Potential).
 CARBOHYD 188 188 N-linked (GlcNAc...).
 CARBOHYD 226 226 N-linked (GlcNAc...) (Potential).
 CARBOHYD 243 243 N-linked (GlcNAc...) (Potential).
 CARBOHYD 353 353 N-linked (GlcNAc...) (Potential).
 CARBOHYD 371 371 N-linked (GlcNAc...) (Potential).
 CARBOHYD 482 482 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Glycoprotein; Membrane; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 612 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 

Interpro

 IPR024881; Tip. 

Pfam

  

SMART

  

PROSITE

 PS51470; FG_GAP 

PRINTS