CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023319
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sex comb on midleg-like protein 2 
Protein Synonyms/Alias
  
Gene Name
 SCML2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
68NDFKVGMKLEARDPRubiquitination[1]
123QPVGTCEKEGDLLQPmethylation[2]
332STSAASLKSLTRDRGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation.
 Moore KE, Carlson SM, Camp ND, Cheung P, James RG, Chua KF, Wolf-Yadlin A, Gozani O.
 Mol Cell. 2013 May 9;50(3):444-56. [PMID: 23583077] 
Functional Description
 Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). 
Sequence Annotation
 REPEAT 33 131 MBT 1.
 REPEAT 139 240 MBT 2.
 DOMAIN 631 700 SAM.
 MOD_RES 256 256 Phosphoserine.
 MOD_RES 267 267 Phosphoserine.
 MOD_RES 299 299 Phosphoserine.
 MOD_RES 300 300 Phosphoserine.
 MOD_RES 305 305 Phosphothreonine.
 MOD_RES 499 499 Phosphoserine.
 MOD_RES 503 503 Phosphothreonine.
 MOD_RES 511 511 Phosphoserine.
 MOD_RES 583 583 Phosphoserine.
 MOD_RES 590 590 Phosphoserine.
 MOD_RES 594 594 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 700 AA 
Protein Sequence
MGQTVNEDSM DVKKENQEKT PQSSTSSVQR DDFHWEEYLK ETGSISAPSE CFRQSQIPPV 60
NDFKVGMKLE ARDPRNATSV CIATVIGITG ARLRLRLDGS DNRNDFWRLV DSPDIQPVGT 120
CEKEGDLLQP PLGYQMNTSS WPMFLLKTLN GSEMASATLF KKEPPKPPLN NFKVGMKLEA 180
IDKKNPYLIC PATIGDVKGD EVHITFDGWS GAFDYWCKYD SRDIFPAGWC RLTGDVLQPP 240
GTSVPIVKNI AKTESSPSEA SQHSMQSPQK TTLILPTQQV RRSSRIKPPG PTAVPKRSSS 300
VKNITPRKKG PNSGKKEKPL PVICSTSAAS LKSLTRDRGM LYKDVASGPC KIVMSTVCVY 360
VNKHGNFGPH LDPKRIQQLP DHFGPGPVNV VLRRIVQACV DCALETKTVF GYLKPDNRGG 420
EVITASFDGE THSIQLPPVN SASFALRFLE NFCHSLQCDN LLSSQPFSSS RGHTHSSAEH 480
DKNQSAKEDV TERQSTKRSP QQTVPYVVPL SPKLPKTKEY ASEGEPLFAG GSAIPKEENL 540
SEDSKSSSLN SGNYLNPACR NPMYIHTSVS QDFSRSVPGT TSSPLVGDIS PKSSPHEVKF 600
QMQRKSEAPS YIAVPDPSVL KQGFSKDPST WSVDEVIQFM KHTDPQISGP LADLFRQHEI 660
DGKALFLLKS DVMMKYMGLK LGPALKLCYY IEKLKEGKYS 700 
Gene Ontology
 GO:0031519; C:PcG protein complex; IDA:UniProtKB.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR021987; DUF3588.
 IPR004092; Mbt.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR021129; SAM_type1. 
Pfam
 PF12140; DUF3588
 PF02820; MBT
 PF00536; SAM_1 
SMART
 SM00561; MBT
 SM00454; SAM 
PROSITE
 PS51079; MBT
 PS50105; SAM_DOMAIN 
PRINTS