CPLM-002529

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-002529

UniProt Accession

MAG_RAT; P07722; P02685; P07723

Genbank Protein ID

M14871; M22357; M16800; X05301; M11721; M36702; V01544

Genbank Nucleotide ID

AAA41556.1; AAA41558.1; AAA41557.1; CAA28920.1; AAA42082.1; AAA40831.1; CAA24786.1

Protein Name

Myelin-associated glycoprotein

Protein Synonyms/Alias

Brain neuron cytoplasmic protein 3; Sialic acid-binding Ig-like lectin 4a; Siglec-4a

Gene Name

Mag

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Rattus norvegicus (Rat)

NCBI Taxa ID

10116

Lysine Modification

Position	Peptide	Type	References
540	ITQTRRKKNVTESPS	ubiquitination	[1]
570	RISGAPDKYESREVS	ubiquitination	[1]

Reference

[1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]

Functional Description

Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid (By similarity).

Sequence Annotation

DOMAIN 22 120 Ig-like V-type.
DOMAIN 139 237 Ig-like C2-type 1.
DOMAIN 241 325 Ig-like C2-type 2.
DOMAIN 327 412 Ig-like C2-type 3.
DOMAIN 413 508 Ig-like C2-type 4.
BINDING 118 118 Sialic acid (By similarity).
LIPID 531 531 S-palmitoyl cysteine.
CARBOHYD 99 99 N-linked (GlcNAc...) (Potential).
CARBOHYD 223 223 N-linked (GlcNAc...) (Potential).
CARBOHYD 246 246 N-linked (GlcNAc...) (Potential).
CARBOHYD 315 315 N-linked (GlcNAc...) (Potential).
CARBOHYD 332 332 N-linked (GlcNAc...) (Potential).
CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
CARBOHYD 450 450 N-linked (GlcNAc...) (Potential).
CARBOHYD 454 454 N-linked (GlcNAc...) (Potential).
DISULFID 37 165 Probable.
DISULFID 42 100 Probable.
DISULFID 159 217 Probable.
DISULFID 261 305 Probable.
DISULFID 347 392 Probable.
DISULFID 421 430 Probable.
DISULFID 432 488 Probable.

Keyword

Alternative splicing; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Lectin; Lipoprotein; Membrane; Palmitate; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

626 AA

Protein Sequence

MIFLTTLPLF WIMISASRGG HWGAWMPSSI SAFEGTCVSI PCRFDFPDEL RPAVVHGVWY 60
FNSPYPKNYP PVVFKSRTQV VHESFQGRSR LLGDLGLRNC TLLLSTLSPE LGGKYYFRGD 120
LGGYNQYTFS EHSVLDIINT PNIVVPPEVV AGTEVEVSCM VPDNCPELRP ELSWLGHEGL 180
GEPTVLGRLR EDEGTWVQVS LLHFVPTREA NGHRLGCQAA FPNTTLQFEG YASLDVKYPP 240
VIVEMNSSVE AIEGSHVSLL CGADSNPPPL LTWMRDGMVL REAVAESLYL DLEEVTPAED 300
GIYACLAENA YGQDNRTVEL SVMYAPWKPT VNGTVVAVEG ETVSILCSTQ SNPDPILTIF 360
KEKQILATVI YESQLQLELP AVTPEDDGEY WCVAENQYGQ RATAFNLSVE FAPIILLESH 420
CAAARDTVQC LCVVKSNPEP SVAFELPSRN VTVNETEREF VYSERSGLLL TSILTLRGQA 480
QAPPRVICTS RNLYGTQSLE LPFQGAHRLM WAKIGPVGAV VAFAILIAIV CYITQTRRKK 540
NVTESPSFSA GDNPHVLYSP EFRISGAPDK YESREVSTRD CH 582

Gene Ontology

GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0033270; C:paranode region of axon; IEA:Compara.
GO:0043220; C:Schmidt-Lanterman incisure; IEA:Compara.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.

Interpro

IPR013162; CD80_C2-set.
IPR007110; Ig-like_dom.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.

Pfam

PF08205; C2-set_2
PF07679; I-set

SMART

SM00409; IG
SM00408; IGc2

PROSITE

PS50835; IG_LIKE

PRINTS