CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008971
UniProt Accession
Genbank Protein ID
 D38224 
Genbank Nucleotide ID
Protein Name
 Annexin A4 
Protein Synonyms/Alias
 36 kDa zymogen granule membrane-associated protein; ZAP36; Annexin IV; Annexin-4; Lipocortin IV 
Gene Name
 Anxa4 
Gene Synonyms/Alias
 Anx4 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
4****METKGGTVKAAacetylation[1]
213LHVFDEYKRISQKDIacetylation[1]
246IVKCMRNKPAYFAERacetylation[1]
259ERLYKSMKGLGTDDSacetylation[1]
300KSLYSFIKGDTSGDYacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis (By similarity). 
Sequence Annotation
 REPEAT 23 83 Annexin 1.
 REPEAT 95 155 Annexin 2.
 REPEAT 179 239 Annexin 3.
 REPEAT 254 314 Annexin 4.
 MOD_RES 7 7 Phosphothreonine (By similarity).
 MOD_RES 213 213 N6-acetyllysine (By similarity).
 MOD_RES 293 293 N6-acetyllysine (By similarity).
 MOD_RES 300 300 N6-acetyllysine (By similarity).  
Keyword
 3D-structure; Acetylation; Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 319 AA 
Protein Sequence
METKGGTVKA ASGFNATEDA QVLRKAMKGL GTDEDAIIGV LACRNTAQRQ EIRTAYKSTI 60
GRDLLEDLKS ELSSNFEQVI LGMMTPTVLY DVQELRRAMK GAGTDEGCLI EILASRNPEE 120
IRRINQTYQQ QYGRSLEEDI CSDTSFMFQR VLVSLTAGGR DEGNYLDDAL VRQDAQDLYE 180
AGEKRWGTDE VKFLSILCSR NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV 240
KCMRNKPAYF AERLYKSMKG LGTDDSTLIR VMVSRAEIDM LDIPANFKRV YGKSLYSFIK 300
GDTSGDYRKV LLILCGGDD 319 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0006887; P:exocytosis; NAS:RGD. 
Interpro
 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002391; AnnexinIV. 
Pfam
 PF00191; Annexin 
SMART
 SM00335; ANX 
PROSITE
 PS00223; ANNEXIN 
PRINTS
 PR00196; ANNEXIN.