| Tag | Content |
|---|
| CPLM ID | CPLM-006703 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | H(+)/Cl(-) exchange transporter ClcA |
Protein Synonyms/Alias | ClC-ec1 |
Gene Name | clcA |
Gene Synonyms/Alias | eriC; yadQ; b0155; JW5012 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 455 | ILARTLAKQEAEQLA | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. |
Sequence Annotation | MOTIF 106 110 Selectivity filter part_1.
MOTIF 146 150 Selectivity filter part_2.
MOTIF 355 359 Selectivity filter part_3.
BINDING 107 107 Chloride.
BINDING 356 356 Chloride; via amide nitrogen.
BINDING 357 357 Chloride; via amide nitrogen.
BINDING 445 445 Chloride. |
Keyword | 3D-structure; Antiport; Cell inner membrane; Cell membrane; Chloride; Complete proteome; Ion transport; Membrane; Reference proteome; Stress response; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 473 AA |
Protein Sequence | MKTDTPSLET PQAARLRRRQ LIRQLLERDK TPLAILFMAA VVGTLVGLAA VAFDKGVAWL 60
QNQRMGALVH TADNYPLLLT VAFLCSAVLA MFGYFLVRKY APEAGGSGIP EIEGALEDQR 120
PVRWWRVLPV KFFGGLGTLG GGMVLGREGP TVQIGGNIGR MVLDIFRLKG DEARHTLLAT 180
GAAAGLAAAF NAPLAGILFI IEEMRPQFRY TLISIKAVFI GVIMSTIMYR IFNHEVALID 240
VGKLSDAPLN TLWLYLILGI IFGIFGPIFN KWVLGMQDLL HRVHGGNITK WVLMGGAIGG 300
LCGLLGFVAP ATSGGGFNLI PIATAGNFSM GMLVFIFVAR VITTLLCFSS GAPGGIFAPM 360
LALGTVLGTA FGMVAVELFP QYHLEAGTFA IAGMGALLAA SIRAPLTGII LVLEMTDNYQ 420
LILPMIITGL GATLLAQFTG GKPLYSAILA RTLAKQEAEQ LARSKAASAS ENT 473 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IDA:EcoCyc. GO:0031404; F:chloride ion binding; IDA:EcoCyc. GO:0015299; F:solute:hydrogen antiporter activity; IDA:EcoCyc. GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro. GO:0006821; P:chloride transport; IDA:EcoCyc. GO:0015706; P:nitrate transport; IDA:EcoCyc. GO:0006950; P:response to stress; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |