UniProt Accession

 BAG5_HUMAN; Q9UL15; O94950; Q86W59 

Genbank Protein ID

 AF095195; AB020680; AL139300; BC044216; BC050551 

Genbank Nucleotide ID

 AAD16124.2; BAA74896.1; AAH44216.2; AAH50551.1 

Protein Name

 BAG family molecular chaperone regulator 5 

Protein Synonyms/Alias

 BAG-5; Bcl-2-associated athanogene 5 

Gene Name

 BAG5 

Gene Synonyms/Alias

 KIAA0873 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	SRLQEIQKEVKSVEQ	ubiquitination	[1]
81	LSDDKNYKKLERILT	ubiquitination	[1]
89	KLERILTKQLFEIDS	ubiquitination	[1, 2]
292	EVVEDINKLLKYLDL	ubiquitination	[1]
295	EDINKLLKYLDLEEE	ubiquitination	[1]
397	KEALEKRKLFACEEH	ubiquitination	[1]
445	RLEELLTKQLLALDA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. 

Sequence Annotation

 DOMAIN 9 86 BAG 1.
 DOMAIN 95 167 BAG 2.
 DOMAIN 182 260 BAG 3.
 DOMAIN 275 350 BAG 4.
 DOMAIN 365 442 BAG 5.  

Keyword

 3D-structure; Alternative splicing; Chaperone; Complete proteome; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 447 AA 

Protein Sequence

Gene Ontology

 GO:0016234; C:inclusion body; IDA:BHF-UCL.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
 GO:0031625; F:ubiquitin protein ligase binding; ISS:BHF-UCL.
 GO:0061084; P:negative regulation of protein refolding; ISS:BHF-UCL.
 GO:0051444; P:negative regulation of ubiquitin-protein ligase activity; ISS:BHF-UCL.
 GO:0070997; P:neuron death; ISS:BHF-UCL.
 GO:0006457; P:protein folding; TAS:ProtInc.
 GO:0090083; P:regulation of inclusion body assembly; IMP:BHF-UCL. 

Interpro

 IPR003103; BAG_domain. 

Pfam

 PF02179; BAG 

SMART

 SM00264; BAG 

PROSITE

 PS51035; BAG 

PRINTS