UniProt Accession

 BDH2_RAT; D4A1J4 

Genbank Protein ID

 CH473952 

Genbank Nucleotide ID

 EDL82248.1 

Protein Name

 3-hydroxybutyrate dehydrogenase type 2 

Protein Synonyms/Alias

 Dehydrogenase/reductase SDR family member 6; R-beta-hydroxybutyrate dehydrogenase 

Gene Name

 Bdh2 

Gene Synonyms/Alias

 Dhrs6 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
42	ATDINEAKLQELENY	acetylation	[1]
61	TRVLDVTKKRQIDQF	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). 

Sequence Annotation

 NP_BIND 10 37 NAD (By similarity).
 NP_BIND 180 184 NAD (By similarity).
 ACT_SITE 147 147 Proton acceptor (By similarity).
 BINDING 58 58 NAD (By similarity).
 BINDING 144 144 Substrate (By similarity).
 BINDING 151 151 NAD (By similarity).
 BINDING 188 188 Substrate (By similarity).
 BINDING 205 205 Substrate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; NAD; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003858; F:3-hydroxybutyrate dehydrogenase activity; IEA:EC.
 GO:0051287; F:NAD binding; IEA:Compara.
 GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; ISS:UniProtKB.
 GO:0006635; P:fatty acid beta-oxidation; IEA:Compara.
 GO:0042168; P:heme metabolic process; ISS:UniProtKB.
 GO:0055072; P:iron ion homeostasis; ISS:UniProtKB.
 GO:0019290; P:siderophore biosynthetic process; ISS:UniProtKB. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

  

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.