CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011207
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Proprotein convertase subtilisin/kexin type 5 
Protein Synonyms/Alias
 Proprotein convertase 5; PC5; Proprotein convertase 6; PC6; Subtilisin-like proprotein convertase 6; SPC6; Subtilisin/kexin-like protease PC5 
Gene Name
 Pcsk5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1804VAKGRYEKLAEPTVSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors (By similarity). 
Sequence Annotation
 DOMAIN 464 602 Homo B/P.
 REGION 117 452 Catalytic.
 REGION 638 1753 CRM (Cys-rich motif).
 REGION 1825 1844 AC 1.
 REGION 1856 1877 AC 2.
 MOTIF 521 523 Cell attachment site (Potential).
 ACT_SITE 173 173 Charge relay system (By similarity).
 ACT_SITE 214 214 Charge relay system (By similarity).
 ACT_SITE 388 388 Charge relay system (By similarity).
 CARBOHYD 227 227 N-linked (GlcNAc...) (Potential).
 CARBOHYD 383 383 N-linked (GlcNAc...) (Potential).
 CARBOHYD 667 667 N-linked (GlcNAc...) (Potential).
 CARBOHYD 754 754 N-linked (GlcNAc...) (Potential).
 CARBOHYD 804 804 N-linked (GlcNAc...) (Potential).
 CARBOHYD 854 854 N-linked (GlcNAc...) (Potential).
 CARBOHYD 951 951 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1016 1016 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1220 1220 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1317 1317 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1523 1523 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1711 1711 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1733 1733 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Glycoprotein; Hydrolase; Membrane; Pregnancy; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal; Transmembrane; Transmembrane helix; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1877 AA 
Protein Sequence
MDWDWGNRCS RPGRRDLLCV LALLAGCLLP VCRTRVYTNH WAVKIAGGFA EADRIASKYG 60
FINVGQIGAL KDYYHFYHSR TIKRSVLSSR GTHSFISMEP KVEWIQQQVV KKRTKRDYDL 120
SHAQSTYFND PKWPSMWYMH CSDNTHPCQS DMNIEGAWKR GYTGKNIVVT ILDDGIERTH 180
PDLMQNYDAL ASCDVNGNDL DPMPRYDASN ENKHGTRCAG EVAATANNSH CTVGIAFNAK 240
IGGVRMLDGD VTDMVEAKSV SYNPQHVHIY SASWGPDDDG KTVDGPAPLT RQAFENGVRM 300
GRRGLGSVFV WASGNGGRSK DHCSCDGYTN SIYTISISST AESGKKPWYL EECSSTLATT 360
YSSGESYDKK IITTDLRQRC TDNHTGTSAS APMAAGIIAL ALEANPFLTW RDVQHVIVRT 420
SRAGHLNAND WKTNAAGFKV SHLYGFGLMD AEAMVMEAEK WTTVPQQHVC VESTDRQIKT 480
IRPNSAVRSI YKASGCSDNP NHHVNYLEHV VVRITITHPR RGDLAIYLTS PSGTRSQLLA 540
NRLFDHSMEG FKNWEFMTIH CWGERAAGDW VLEVYDTPSQ LRNFKTPGKL KEWSLVLYGT 600
SVQPYSPTNE FPKVERFRYS RVEDPTDDYG AEDYAGPCDP ECSEVGCDGP GPDHCSDCLH 660
YYYKLKNNTR ICVSSCPPGH YHADKKRCRK CAPNCESCFG SHGNQCLSCK YGYFLNEETS 720
SCVTQCPDGS YEDIKKNVCG KCSENCKACI GFHNCTECKG GLSLQGSRCS VTCEDGQFFN 780
GHDCQPCHRF CATCSGAGAD GCINCTEGYV MEEGRCVQSC SVSYYLDHSS EGGYKSCKRC 840
DNSCLTCNGP GFKNCSSCPS GYLLDLGTCQ MGAICKDGEY IDDQGHCQTC EASCAKCWGP 900
TQEDCISCPV TRVLDDGRCV MNCPSWKFEF KKQCHPCHYT CQGCQGSGPS NCTSCRADKH 960
GQERFLYHGE CLENCPVGHY PAKGHACLPC PDNCELCYNP HVCSRCMSGY VIIPPNHTCQ 1020
KLECRQGEFQ DSEYEECMPC EEGCLGCTED DPGACTSCAT GYYMFERHCY KACPEKTFGV 1080
KWECRACGTN CGSCDQHECY WCEEGFFLSG GSCVQDCGPG FHGDQELGEC KPCHRACENC 1140
TGSGYNQCSS CQEGLQLWHG TCLWSTWPQV EGKDWNEAVP TEKPSLVRSL LQDRRKWKVQ 1200
IKRDATSQNQ PCHSSCKTCN GSLCASCPTG MYLWLQACVP SCPQGTWPSV TSGSCEKCSE 1260
DCVSCSGADL CQQCLSQPDN TLLLHEGRCY HSCPEGFYAK DGVCEHCSSP CKTCEGNATS 1320
CNSCEGDFVL DHGVCWKTCP EKHVAVEGVC KHCPERCQDC IHEKTCKECM PDFFLYNDMC 1380
HRSCPKSFYP DMRQCVPCHK NCLECNGPKE DDCKVCADTS KALHNGLCLD ECPEGTYKEE 1440
ENDECRDCPE SCLICSSAWT CLACREGFTV VHDVCTAPKE CAAVEYWDEG SHRCQPCHKK 1500
CSRCSGPSED QCYTCPRETF LLNTTCVKEC PEGYHTDKDS QQCVLCHSSC RTCEGPHSMQ 1560
CLSCRPGWFQ LGKECLLQCR DGYYGESTSG RCEKCDKSCK SCRGPRPTDC QSCDTFFFLL 1620
RSKGQCHRAC PEHYYADQHA QTCERCHPTC DKCSGKEAWS CLSCVWSYHL LKGICIPECI 1680
VGEYREGKGE NFNCKKCHES CMECKGPGSK NCTGCSAGLL LDMDDNRCLH CCNASHSRRS 1740
QDCCDCQSST DECILPAREA EFYEHTKTAL LVTSGAMLLL LLGAAAVVWR KSRSRPVAKG 1800
RYEKLAEPTV SYSSYRSSYL DEDQVIEYRD RDYDEDDEDD IVYMGQDGTV YRKFKYGLLD 1860
ETEDDELEYD DESYSYQ 1877 
Gene Ontology
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030141; C:secretory granule; IDA:MGI.
 GO:0042277; F:peptide binding; IDA:BHF-UCL.
 GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL.
 GO:0009952; P:anterior/posterior pattern specification; IMP:BHF-UCL.
 GO:0042089; P:cytokine biosynthetic process; IDA:BHF-UCL.
 GO:0007566; P:embryo implantation; IMP:BHF-UCL.
 GO:0048566; P:embryonic digestive tract development; IMP:BHF-UCL.
 GO:0048706; P:embryonic skeletal system development; IMP:BHF-UCL.
 GO:0007507; P:heart development; IMP:BHF-UCL.
 GO:0001822; P:kidney development; IMP:BHF-UCL.
 GO:0035108; P:limb morphogenesis; IMP:BHF-UCL.
 GO:0043043; P:peptide biosynthetic process; IDA:BHF-UCL.
 GO:0016486; P:peptide hormone processing; IDA:BHF-UCL.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0002001; P:renin secretion into blood stream; IEA:Compara.
 GO:0030323; P:respiratory tube development; IMP:BHF-UCL.
 GO:0006465; P:signal peptide processing; IEA:Compara.
 GO:0019067; P:viral assembly, maturation, egress, and release; IDA:BHF-UCL. 
Interpro
 IPR000742; EG-like_dom.
 IPR006212; Furin_repeat.
 IPR008979; Galactose-bd-like.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR000209; Peptidase_S8/S53_dom.
 IPR023827; Peptidase_S8_Asp-AS.
 IPR022398; Peptidase_S8_His-AS.
 IPR023828; Peptidase_S8_Ser-AS.
 IPR015500; Peptidase_S8_subtilisin-rel.
 IPR009020; Prot_inh_propept.
 IPR002884; PrprotnconvertsP. 
Pfam
 PF01483; P_proprotein
 PF00082; Peptidase_S8 
SMART
 SM00181; EGF
 SM00261; FU 
PROSITE
 PS00136; SUBTILASE_ASP
 PS00137; SUBTILASE_HIS
 PS00138; SUBTILASE_SER 
PRINTS
 PR00723; SUBTILISIN.