UniProt Accession

 NR2E3_MOUSE; Q9QXZ7 

Genbank Protein ID

 AF148129; AF204053; BC017521 

Genbank Nucleotide ID

 AAF22228.1; AAF69682.1; AAH17521.1 

Protein Name

 Photoreceptor-specific nuclear receptor 

Protein Synonyms/Alias

 Nuclear receptor subfamily 2 group E member 3; Retina-specific nuclear receptor 

Gene Name

 Nr2e3 

Gene Synonyms/Alias

 Pnr; Rnr 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
178	ITAETCAKLEPEDAE	sumoylation	[1]
315	LKALVLFKPETRGLK	sumoylation	[1]
322	KPETRGLKDPEHVEA	sumoylation	[1]

Reference

 [1] Pias3-dependent SUMOylation directs rod photoreceptor development.
 Onishi A, Peng GH, Hsu C, Alexis U, Chen S, Blackshaw S.
 Neuron. 2009 Jan 29;61(2):234-46. [PMID: 19186166] 

Functional Description

 Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. 

Sequence Annotation

 DNA_BIND 37 113 Nuclear receptor.
 ZN_FING 40 60 NR C4-type.
 ZN_FING 76 101 NR C4-type.
 MOD_RES 318 318 Phosphothreonine (By similarity).
 CROSSLNK 178 178 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 315 315 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 322 322 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Complete proteome; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 395 AA 

Protein Sequence

Gene Ontology

 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0042462; P:eye photoreceptor cell development; IMP:MGI.
 GO:0030522; P:intracellular receptor signaling pathway; IEA:GOC.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0045872; P:positive regulation of rhodopsin gene expression; IGI:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0060041; P:retina development in camera-type eye; IMP:MGI. 

Interpro

 IPR003068; COUP_TF.
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF00104; Hormone_recep
 PF00105; zf-C4 

SMART

 SM00430; HOLI
 SM00399; ZnF_C4 

PROSITE

 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 

PRINTS

 PR01282; COUPTNFACTOR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.